The capsular polysaccharide synthesis locus analysis of Streptococcus suis isolates

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F22%3AN0000133" target="_blank" >RIV/00027162:_____/22:N0000133 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.hostpathogen.com/program-speakers" target="_blank" >https://www.hostpathogen.com/program-speakers</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The capsular polysaccharide synthesis locus analysis of Streptococcus suis isolates

Popis výsledku v původním jazyce

Streptococcus suis is an important pig pathogen that occurs worldwide and causes great economic losses. One of the important virulent factors of this zoonotic agent is its capsular polysaccharide (CPS). Based on the structure and composition of the capsular polysaccharide, we distinguish S. suis serotypes. Due to its phenotypic and genotypic diversity, more than 33 serotypes are currently known. 123 field samples of S. suis from Czech farms were sequenced and their cps synthesis loci were compared with reference serotypes. After comparing the cps loci, it was found that there is a group in our collection whose isolates can be classified into previously reported serotypes. The second group of isolates were similar to the reference serotypes, but had either mutations or gene insertions/deletions. Other isolates have been grouped as having cps loci identical to recently described novel cps loci (NCLs) and other strains have NCLs not yet described. This indicates the great diversity of S. suis in the Czech republic. This work was supported by Ministry of Agriculture of the Czech Republic (Institutional Support No. MZE-RO0518) and by the National Agency for Agricultural Research (Project No. QK1810193).

Název v anglickém jazyce

The capsular polysaccharide synthesis locus analysis of Streptococcus suis isolates

Popis výsledku anglicky

Streptococcus suis is an important pig pathogen that occurs worldwide and causes great economic losses. One of the important virulent factors of this zoonotic agent is its capsular polysaccharide (CPS). Based on the structure and composition of the capsular polysaccharide, we distinguish S. suis serotypes. Due to its phenotypic and genotypic diversity, more than 33 serotypes are currently known. 123 field samples of S. suis from Czech farms were sequenced and their cps synthesis loci were compared with reference serotypes. After comparing the cps loci, it was found that there is a group in our collection whose isolates can be classified into previously reported serotypes. The second group of isolates were similar to the reference serotypes, but had either mutations or gene insertions/deletions. Other isolates have been grouped as having cps loci identical to recently described novel cps loci (NCLs) and other strains have NCLs not yet described. This indicates the great diversity of S. suis in the Czech republic. This work was supported by Ministry of Agriculture of the Czech Republic (Institutional Support No. MZE-RO0518) and by the National Agency for Agricultural Research (Project No. QK1810193).

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

<a href="/cs/project/QK1810193" target="_blank" >QK1810193: Moderní metody diagnostiky, terapie a prevence infekcí Streptococcus suis jako nástroj pro sestavování cílených kontrolních programů v chovech prasat</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů