Analysis of the capsular polysaccharide synthesis locus in a collection of Streptococcus suis field isolates isolated in the Czech Republic

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F23%3AN0000052" target="_blank" >RIV/00027162:_____/23:N0000052 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Analysis of the capsular polysaccharide synthesis locus in a collection of Streptococcus suis field isolates isolated in the Czech Republic

Popis výsledku v původním jazyce

Streptococcus suis is considered an important bacterial swine pathogen responsible for various diseases such as meningitis, endocarditis, arthritis, and septicemia leading to sudden death and therefore contributes to significant economic losses in the swine industry. In addition, S. suis is a zoonotic pathogen that can be transmitted to humans and cause disease, mainly arthritis, meningitis and streptococcal toxic shock-like syndrome. One of the main virulence factors is the presence of capsular polysaccharide (CPS). There are 29 serotypes based on serological reactions against the CPS, but serologically untypeable strains are often found, which suggests that S. suis has more serotypes than has been reported so far. Recently, the novel cps loci (NCLs) were identified in non-serotypeable isolates. Strains of Streptococcus suis are genotypically and phenotypically very different, and strains of the same serotype can differ significantly at the genomic level. We performed an analysis of capsular polysaccharide synthesis loci in 123 field samples isolated from diseased farm animals in the Czech Republic in 2018-2020.

Název v anglickém jazyce

Analysis of the capsular polysaccharide synthesis locus in a collection of Streptococcus suis field isolates isolated in the Czech Republic

Popis výsledku anglicky

Streptococcus suis is considered an important bacterial swine pathogen responsible for various diseases such as meningitis, endocarditis, arthritis, and septicemia leading to sudden death and therefore contributes to significant economic losses in the swine industry. In addition, S. suis is a zoonotic pathogen that can be transmitted to humans and cause disease, mainly arthritis, meningitis and streptococcal toxic shock-like syndrome. One of the main virulence factors is the presence of capsular polysaccharide (CPS). There are 29 serotypes based on serological reactions against the CPS, but serologically untypeable strains are often found, which suggests that S. suis has more serotypes than has been reported so far. Recently, the novel cps loci (NCLs) were identified in non-serotypeable isolates. Strains of Streptococcus suis are genotypically and phenotypically very different, and strains of the same serotype can differ significantly at the genomic level. We performed an analysis of capsular polysaccharide synthesis loci in 123 field samples isolated from diseased farm animals in the Czech Republic in 2018-2020.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

<a href="/cs/project/QK1810193" target="_blank" >QK1810193: Moderní metody diagnostiky, terapie a prevence infekcí Streptococcus suis jako nástroj pro sestavování cílených kontrolních programů v chovech prasat</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů