Innate immune response of common Carp (Cyprinus carpio L.) to Koi herpesvirus infection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F22%3AN0000135" target="_blank" >RIV/00027162:_____/22:N0000135 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Innate immune response of common Carp (Cyprinus carpio L.) to Koi herpesvirus infection

Popis výsledku v původním jazyce

Common carp is the most economically important fish in Czech Republic. However, a profit, earned by breeding of common carp, may be reduced by many diseases, among which viral diseases are the most serious matter. Koi herpesvirus (KHV) disease is probably the most serious viral disease affecting common carp. KHV disease affects only common carp, its strains and some hybrids of common carp and other cyprinids. KHV disease morbidity and mortality can reach one hundred percent, especially in juvenile individuals. Mortality rates of KHV disease could be significantly different among different strains of common carp. Further, KHV is able to kill diseased carp within one week after infection. Importance of KHV disease is even higher, because neither effective KHV treatment nor vaccine are available on the market in EU. The aim of presented study is to show current discoveries in innate immune response of common carp to KHV. Immune responses to KHV of two common carp breeds were compared: amur wild carp, which is highly resistant to KHV and Koi carp, which is susceptible to KHV. Analysis was focused on known antiviral immune response mechanisms, in particular class I interferon signalling, mechanism of complement cascade and cell-mediated cytotoxicity.

Název v anglickém jazyce

Innate immune response of common Carp (Cyprinus carpio L.) to Koi herpesvirus infection

Popis výsledku anglicky

Common carp is the most economically important fish in Czech Republic. However, a profit, earned by breeding of common carp, may be reduced by many diseases, among which viral diseases are the most serious matter. Koi herpesvirus (KHV) disease is probably the most serious viral disease affecting common carp. KHV disease affects only common carp, its strains and some hybrids of common carp and other cyprinids. KHV disease morbidity and mortality can reach one hundred percent, especially in juvenile individuals. Mortality rates of KHV disease could be significantly different among different strains of common carp. Further, KHV is able to kill diseased carp within one week after infection. Importance of KHV disease is even higher, because neither effective KHV treatment nor vaccine are available on the market in EU. The aim of presented study is to show current discoveries in innate immune response of common carp to KHV. Immune responses to KHV of two common carp breeds were compared: amur wild carp, which is highly resistant to KHV and Koi carp, which is susceptible to KHV. Analysis was focused on known antiviral immune response mechanisms, in particular class I interferon signalling, mechanism of complement cascade and cell-mediated cytotoxicity.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

<a href="/cs/project/EF16_019%2F0000869" target="_blank" >EF16_019/0000869: Udržitelná produkce zdravých ryb v různých akvakulturních systémech - PROFISH</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů