APC/C activity during transition from meiosis into mitosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F23%3AN0000224" target="_blank" >RIV/00027162:_____/23:N0000224 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

APC/C activity during transition from meiosis into mitosis

Popis výsledku v původním jazyce

Early development in mammals is characterized by dramatic events, such as two consecutive meiotic divisions, fertilization and early cleavage cycles of blastomeres in the newly formed embryo. Moreover, during meiosis and the first embryonic cleavage cycles, cells remain transcriptionally silent, which renders regulated translation, posttranslational modifications and proteolysis essential for controlling cell cycle and chromosome segregation. During this period, oocytes, as well as blastomeres of early embryos, frequently suffer from aneuploidy. In fact, aneuploidy is the leading cause of failure of early development in mammals, including human. It is therefore vital to obtain better understanding of the cell cycle regulatory mechanisms during this period. In our study, we focused on the maintenance of essential cell cycle regulatory proteins, such as cyclins and securin, during transition from meiosis into mitosis, when the cells are transcriptionally silent.

Název v anglickém jazyce

APC/C activity during transition from meiosis into mitosis

Popis výsledku anglicky

Early development in mammals is characterized by dramatic events, such as two consecutive meiotic divisions, fertilization and early cleavage cycles of blastomeres in the newly formed embryo. Moreover, during meiosis and the first embryonic cleavage cycles, cells remain transcriptionally silent, which renders regulated translation, posttranslational modifications and proteolysis essential for controlling cell cycle and chromosome segregation. During this period, oocytes, as well as blastomeres of early embryos, frequently suffer from aneuploidy. In fact, aneuploidy is the leading cause of failure of early development in mammals, including human. It is therefore vital to obtain better understanding of the cell cycle regulatory mechanisms during this period. In our study, we focused on the maintenance of essential cell cycle regulatory proteins, such as cyclins and securin, during transition from meiosis into mitosis, when the cells are transcriptionally silent.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

40203 - Husbandry

Projekt

<a href="/cs/project/GA20-25850S" target="_blank" >GA20-25850S: Kontrola vstupu do anafáze během časného vývoje</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů