Chromosome Division in Early Embryos-Is Everything under Control? And Is the Cell Size Important?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F24%3A00584104" target="_blank" >RIV/67985904:_____/24:00584104 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/24:00135722 RIV/00027162:_____/24:N0000014

Výsledek na webu

<a href="https://www.mdpi.com/1422-0067/25/4/2101" target="_blank" >https://www.mdpi.com/1422-0067/25/4/2101</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms25042101" target="_blank" >10.3390/ijms25042101</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chromosome Division in Early Embryos-Is Everything under Control? And Is the Cell Size Important?

Popis výsledku v původním jazyce

Chromosome segregation in female germ cells and early embryonic blastomeres is known to be highly prone to errors. The resulting aneuploidy is therefore the most frequent cause of termination of early development and embryo loss in mammals. And in specific cases, when the aneuploidy is actually compatible with embryonic and fetal development, it leads to severe developmental disorders. The main surveillance mechanism, which is essential for the fidelity of chromosome segregation, is the Spindle Assembly Checkpoint (SAC). And although all eukaryotic cells carry genes required for SAC, it is not clear whether this pathway is active in all cell types, including blastomeres of early embryos. In this review, we will summarize and discuss the recent progress in our understanding of the mechanisms controlling chromosome segregation and how they might work in embryos and mammalian embryos in particular. Our conclusion from the current literature is that the early mammalian embryos show limited capabilities to react to chromosome segregation defects, which might, at least partially, explain the widespread problem of aneuploidy during the early development in mammals.

Název v anglickém jazyce

Chromosome Division in Early Embryos-Is Everything under Control? And Is the Cell Size Important?

Popis výsledku anglicky

Chromosome segregation in female germ cells and early embryonic blastomeres is known to be highly prone to errors. The resulting aneuploidy is therefore the most frequent cause of termination of early development and embryo loss in mammals. And in specific cases, when the aneuploidy is actually compatible with embryonic and fetal development, it leads to severe developmental disorders. The main surveillance mechanism, which is essential for the fidelity of chromosome segregation, is the Spindle Assembly Checkpoint (SAC). And although all eukaryotic cells carry genes required for SAC, it is not clear whether this pathway is active in all cell types, including blastomeres of early embryos. In this review, we will summarize and discuss the recent progress in our understanding of the mechanisms controlling chromosome segregation and how they might work in embryos and mammalian embryos in particular. Our conclusion from the current literature is that the early mammalian embryos show limited capabilities to react to chromosome segregation defects, which might, at least partially, explain the widespread problem of aneuploidy during the early development in mammals.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/GA19-24528S" target="_blank" >GA19-24528S: Vztah mezi velikostí buňky a buněčných organel během časného vývoje savčích embryí</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Molecular Sciences

ISSN

1661-6596

e-ISSN

1422-0067

Svazek periodika

25

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

14

Strana od-do

2101

Kód UT WoS článku

001172049100001

EID výsledku v databázi Scopus

2-s2.0-85185954676