Regulation of the cell cycle in early mammalian embryos and its clinical implications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F19%3AN0000297" target="_blank" >RIV/00027162:_____/19:N0000297 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/s41598-019-40035-5" target="_blank" >https://www.nature.com/articles/s41598-019-40035-5</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Regulation of the cell cycle in early mammalian embryos and its clinical implications

Popis výsledku v původním jazyce

Early embryonic development is characterized by a plethora of very complex and simul¬taneously operating processes, which are constantly changing cellular morphology and behaviour. After fertilization, blastomeres of the newly created embryo undergo global epigenetic changes and simultaneously initiate transcription from the zygotic genome and differentiation forming separate cell lineages. Some of these mechanisms were extensively studied during the last several decades and valuable insight was gained into how these processes are regulated at the molecular level. We have, however, a still very limited understanding of how multiple events are coordinated during rapid development of an early mammalian embryo. In this review, we discuss some aspects of early embryonic development in mammals, namely the fidelity of chromosome segregation and occur¬rence of aneuploidy, as well as the clinical applications of cell cycle monitoring in human embryos.

Název v anglickém jazyce

Regulation of the cell cycle in early mammalian embryos and its clinical implications

Popis výsledku anglicky

Early embryonic development is characterized by a plethora of very complex and simul¬taneously operating processes, which are constantly changing cellular morphology and behaviour. After fertilization, blastomeres of the newly created embryo undergo global epigenetic changes and simultaneously initiate transcription from the zygotic genome and differentiation forming separate cell lineages. Some of these mechanisms were extensively studied during the last several decades and valuable insight was gained into how these processes are regulated at the molecular level. We have, however, a still very limited understanding of how multiple events are coordinated during rapid development of an early mammalian embryo. In this review, we discuss some aspects of early embryonic development in mammals, namely the fidelity of chromosome segregation and occur¬rence of aneuploidy, as well as the clinical applications of cell cycle monitoring in human embryos.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10605 - Developmental biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International journal of developmental biology

ISSN

0214-6282

e-ISSN

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Svazek periodika

63

Číslo periodika v rámci svazku

3-5

Stát vydavatele periodika

ES - Španělské království

Počet stran výsledku

11

Strana od-do

113-122

Kód UT WoS článku

000464941000006

EID výsledku v databázi Scopus

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