Might great variability of porcine rotavirus a hamper the vaccine efficacy in pigs?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F24%3AN0000071" target="_blank" >RIV/00027162:_____/24:N0000071 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Might great variability of porcine rotavirus a hamper the vaccine efficacy in pigs?

Popis výsledku v původním jazyce

Rotaviruses (RVs) belong to the Reoviridae family and are a major cause of acute viral gastroenteritis in young animals, including piglets. During our study in 2016-2019, 167 samples of domestic pigs faeces were screened for the presence of RVA and 44.9% were tested positive (n=75). The most common porcine G-genotypes were G9 (36% of all RVA-positive samples), G4 (26%), G5 (17%), and G11 (12%) in combination with different P-types (mostly with P[6] and P[13]). Most commercial farms in the Czech Republic use rotavirus vaccines intended for the active immunization of pregnant sows and gilts for the induction of colostral and lactogenic immunity in newborn piglets. However, those vaccines include only RVA strain OSU which is of G5P[7] genotype. The ongoing surveillance of porcine RVA genotypes (2020-2023) showed another increase in non-G5 genotypes representation (50% of G9, 28% of G4, and 7% of G9). Only 5% of successfully genotyped samples were of G5 genotype. Similar changes in the human RVA genotypes proportions were demonstrated in several large-scale molecular epidemiological studies after introduction of the vaccination in different countries suggesting the possibility of RVA escape from vaccine-induced immune pressure. Therefore, continuing surveillance studies of porcine rotavirus genotypes are needed to monitor the dynamics of RVA and to be able to responsibly evaluate the effectiveness of RVA vaccines used in swine production.

Název v anglickém jazyce

Might great variability of porcine rotavirus a hamper the vaccine efficacy in pigs?

Popis výsledku anglicky

Rotaviruses (RVs) belong to the Reoviridae family and are a major cause of acute viral gastroenteritis in young animals, including piglets. During our study in 2016-2019, 167 samples of domestic pigs faeces were screened for the presence of RVA and 44.9% were tested positive (n=75). The most common porcine G-genotypes were G9 (36% of all RVA-positive samples), G4 (26%), G5 (17%), and G11 (12%) in combination with different P-types (mostly with P[6] and P[13]). Most commercial farms in the Czech Republic use rotavirus vaccines intended for the active immunization of pregnant sows and gilts for the induction of colostral and lactogenic immunity in newborn piglets. However, those vaccines include only RVA strain OSU which is of G5P[7] genotype. The ongoing surveillance of porcine RVA genotypes (2020-2023) showed another increase in non-G5 genotypes representation (50% of G9, 28% of G4, and 7% of G9). Only 5% of successfully genotyped samples were of G5 genotype. Similar changes in the human RVA genotypes proportions were demonstrated in several large-scale molecular epidemiological studies after introduction of the vaccination in different countries suggesting the possibility of RVA escape from vaccine-induced immune pressure. Therefore, continuing surveillance studies of porcine rotavirus genotypes are needed to monitor the dynamics of RVA and to be able to responsibly evaluate the effectiveness of RVA vaccines used in swine production.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

<a href="/cs/project/TN02000017" target="_blank" >TN02000017: Národní Centrum Biotechnologií ve Veterinární Medicíně</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů