Assessing earthworm exposure to a multi-pharmaceutical mixture in soil: unveiling insights through LC–MS and MALDI-MS analyses, and impact of biochar on pharmaceutical bioavailability

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F24%3AN0000073" target="_blank" >RIV/00027162:_____/24:N0000073 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26310/24:PU151659

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s11356-024-34389-1" target="_blank" >https://link.springer.com/article/10.1007/s11356-024-34389-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11356-024-34389-1" target="_blank" >10.1007/s11356-024-34389-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Assessing earthworm exposure to a multi-pharmaceutical mixture in soil: unveiling insights through LC–MS and MALDI-MS analyses, and impact of biochar on pharmaceutical bioavailability

Popis výsledku v původním jazyce

In the European circular economy, agricultural practices introduce pharmaceutical (PhAC) residues into the terrestrial environment, posing a potential risk to earthworms. This study aimed to assess earthworm bioaccumulation factors (BAFs), the ecotoxicological effects of PhACs, the impact of biochar on PhAC bioavailability to earthworms, and their persistence in soil and investigate earthworm uptake mechanisms along with the spatial distribution of PhACs. Therefore, earthworms were exposed to contaminated soil for 21 days. The results revealed that BAFs ranged from 0.0216 to 0.329, with no significant ecotoxicological effects on earthworm weight or mortality (p > 0.05). Biochar significantly influenced the uptake of 14 PhACs on the first day (p < 0.05), with diminishing effects over time, and affected significantly the soil-degradation kinetics of 16 PhACs. Moreover, MALDI-MS analysis revealed that PhAC uptake occurs through both the dermal and oral pathways, as pharmaceuticals were distributed throughout the entire earthworm tissue without specific localization. In conclusion, this study suggests ineffective PhAC accumulation in earthworms, highlights the influence of biochar on PhAC degradation rates in soil, and suggests that uptake can occur through both earthworm skin and oral ingestion.

Název v anglickém jazyce

Assessing earthworm exposure to a multi-pharmaceutical mixture in soil: unveiling insights through LC–MS and MALDI-MS analyses, and impact of biochar on pharmaceutical bioavailability

Popis výsledku anglicky

In the European circular economy, agricultural practices introduce pharmaceutical (PhAC) residues into the terrestrial environment, posing a potential risk to earthworms. This study aimed to assess earthworm bioaccumulation factors (BAFs), the ecotoxicological effects of PhACs, the impact of biochar on PhAC bioavailability to earthworms, and their persistence in soil and investigate earthworm uptake mechanisms along with the spatial distribution of PhACs. Therefore, earthworms were exposed to contaminated soil for 21 days. The results revealed that BAFs ranged from 0.0216 to 0.329, with no significant ecotoxicological effects on earthworm weight or mortality (p > 0.05). Biochar significantly influenced the uptake of 14 PhACs on the first day (p < 0.05), with diminishing effects over time, and affected significantly the soil-degradation kinetics of 16 PhACs. Moreover, MALDI-MS analysis revealed that PhAC uptake occurs through both the dermal and oral pathways, as pharmaceuticals were distributed throughout the entire earthworm tissue without specific localization. In conclusion, this study suggests ineffective PhAC accumulation in earthworms, highlights the influence of biochar on PhAC degradation rates in soil, and suggests that uptake can occur through both earthworm skin and oral ingestion.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Science and Pollution Research

ISSN

0944-1344

e-ISSN

1614-7499

Svazek periodika

31

Číslo periodika v rámci svazku

35

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

18

Strana od-do

48351–48368

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85199006196