Optimization and validation of multiresidual extraction methods for pharmaceuticals in Soil, Lettuce, and Earthworms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F24%3APU151243" target="_blank" >RIV/00216305:26310/24:PU151243 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s11356-024-33492-7" target="_blank" >https://link.springer.com/article/10.1007/s11356-024-33492-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11356-024-33492-7" target="_blank" >10.1007/s11356-024-33492-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Optimization and validation of multiresidual extraction methods for pharmaceuticals in Soil, Lettuce, and Earthworms

Popis výsledku v původním jazyce

The presence of human and veterinary pharmaceuticals (PhACs) in the environment poses potential risks. To comprehensively assess these risks, robust multiresidual analytical methods are essential for determining a broad spectrum of PhAC classes in various environmental compartments (soil, plants, and soil organisms). This study optimized extraction methods for analyzing over 40 PhACs from various matrices, including soil, lettuce, and earthworms. A four-step ultrasonic extraction method with varying extraction conditions and subsequent solid phase extraction was developed for soil samples. QuEChERS methods were optimized for extracting PhACs from lettuce and earthworm samples, addressing a literature gap in these less-studied matrices. The quantification of PhACs in soil, lettuce, and earthworm extracts was performed using a single LC-MS/MS method. Following thorough method validation, earthworms and lettuce were exposed to a mixture of 27 pharmaceuticals in a soil environment. The method validation results demonstrated the robustness of these methods for a broad spectrum of PhACs. Specifically, 29 out of 42 PhACs were extracted with an average efficiency >50% and RSD <30% from the soil; 40 out of 42 PhACs exhibited average efficiency >50% and %RSD <30% from the earthworms, while 39 out of 42 PhACs showed average efficiency >50% and RSD <30% from the lettuce. Exposure experiments confirmed the viability of these methods for quantifying a diverse range of PhACs in different environmental compartments. This study presents three thoroughly validated methods for determining more than 40 PhACs in diverse matrices, enabling a comprehensive assessment of PhAC dissemination in the environment.

Název v anglickém jazyce

Optimization and validation of multiresidual extraction methods for pharmaceuticals in Soil, Lettuce, and Earthworms

Popis výsledku anglicky

The presence of human and veterinary pharmaceuticals (PhACs) in the environment poses potential risks. To comprehensively assess these risks, robust multiresidual analytical methods are essential for determining a broad spectrum of PhAC classes in various environmental compartments (soil, plants, and soil organisms). This study optimized extraction methods for analyzing over 40 PhACs from various matrices, including soil, lettuce, and earthworms. A four-step ultrasonic extraction method with varying extraction conditions and subsequent solid phase extraction was developed for soil samples. QuEChERS methods were optimized for extracting PhACs from lettuce and earthworm samples, addressing a literature gap in these less-studied matrices. The quantification of PhACs in soil, lettuce, and earthworm extracts was performed using a single LC-MS/MS method. Following thorough method validation, earthworms and lettuce were exposed to a mixture of 27 pharmaceuticals in a soil environment. The method validation results demonstrated the robustness of these methods for a broad spectrum of PhACs. Specifically, 29 out of 42 PhACs were extracted with an average efficiency >50% and RSD <30% from the soil; 40 out of 42 PhACs exhibited average efficiency >50% and %RSD <30% from the earthworms, while 39 out of 42 PhACs showed average efficiency >50% and RSD <30% from the lettuce. Exposure experiments confirmed the viability of these methods for quantifying a diverse range of PhACs in different environmental compartments. This study presents three thoroughly validated methods for determining more than 40 PhACs in diverse matrices, enabling a comprehensive assessment of PhAC dissemination in the environment.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

10406 - Analytical chemistry

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

ISSN

0944-1344

e-ISSN

1614-7499

Svazek periodika

31

Číslo periodika v rámci svazku

24

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

21

Strana od-do

33120-33140

Kód UT WoS článku

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EID výsledku v databázi Scopus

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