Immune response in diseased and healthy common carp exposed to carp edema virus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F24%3AN0000091" target="_blank" >RIV/00027162:_____/24:N0000091 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/24:00138938 RIV/62156489:43210/24:43925635 RIV/62157124:16270/24:43881460

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1111/jfd.14012" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/jfd.14012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jfd.14012" target="_blank" >10.1111/jfd.14012</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Immune response in diseased and healthy common carp exposed to carp edema virus

Popis výsledku v původním jazyce

Common carp is one of the most economically valuable freshwater fish worldwide and its aquaculture can be severely affected by the carp edema virus disease (CEVD). The current study is based on a natural outbreak of CEVD with both clinically healthy and diseased fish of various origin, simultaneously present in one pond and exposed to the virus. The mRNA expression of genes to be associated with the known antiviral immune mechanisms such as type I interferon signalling and cell-mediated cytotoxicity was detected and quantified. Furthermore, complete protein expression profile was used for description of differences between these groups in various tissues. Significant differences in expression profiles of common carp with and without clinical signs were strongly dependent on the organ from which the sample originated. The complement cascade components such as various C3 proteins were upregulated only in the less affected tissues of head kidney and spleen. Other complement proteins such as B/C2 and C9 were upregulated in kidney, spleen and gills, but not in skin. On the other hand, lysozymes C and G, were observed upregulated in the most affected tissues of skin and gills.

Název v anglickém jazyce

Immune response in diseased and healthy common carp exposed to carp edema virus

Popis výsledku anglicky

Common carp is one of the most economically valuable freshwater fish worldwide and its aquaculture can be severely affected by the carp edema virus disease (CEVD). The current study is based on a natural outbreak of CEVD with both clinically healthy and diseased fish of various origin, simultaneously present in one pond and exposed to the virus. The mRNA expression of genes to be associated with the known antiviral immune mechanisms such as type I interferon signalling and cell-mediated cytotoxicity was detected and quantified. Furthermore, complete protein expression profile was used for description of differences between these groups in various tissues. Significant differences in expression profiles of common carp with and without clinical signs were strongly dependent on the organ from which the sample originated. The complement cascade components such as various C3 proteins were upregulated only in the less affected tissues of head kidney and spleen. Other complement proteins such as B/C2 and C9 were upregulated in kidney, spleen and gills, but not in skin. On the other hand, lysozymes C and G, were observed upregulated in the most affected tissues of skin and gills.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

<a href="/cs/project/EF16_019%2F0000869" target="_blank" >EF16_019/0000869: Udržitelná produkce zdravých ryb v různých akvakulturních systémech - PROFISH</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Fish Diseases

ISSN

0140-7775

e-ISSN

1365-2761

Svazek periodika

47

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

"e14012"

Kód UT WoS článku

001306205700001

EID výsledku v databázi Scopus

2-s2.0-85203264597