Spontaneous exophytic tumour in Nothobranchius furzeri, an aging research model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F24%3AN0000123" target="_blank" >RIV/00027162:_____/24:N0000123 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/24:00137287

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1111/jfd.14021" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/jfd.14021</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jfd.14021" target="_blank" >10.1111/jfd.14021</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Spontaneous exophytic tumour in Nothobranchius furzeri, an aging research model

Popis výsledku v původním jazyce

Understanding the nature and diversity of spontaneous neoplasias in a model organism is of peculiar interest to toxicologists and biogerontologists who assess their prevalence in relation to experimental treatments (Wolf et al., 2015). In fishes, exophytic neoplasias are frequently found due to their conspicuous appearance on the body (Roberts, 2012; Vergneau-Grosset et al., 2017). Papillomas are the most common exophytic epithelial fish tumours with a predominant proliferation of epidermal cells with no to little presence of connective tissue (Roberts, 2012). Other exophytic tumours are derived from connective tissue as in fibromas, myxomas and fibromyxomas. Myxomas are soft tumours formed by immature connective tissue with extensive myxoid stroma. In contrast, a fibroma is a firm tumour derived from fibrous connective tissue (Roberts, 2012). Fibromyxomas share some traits of myxoma and fibroma and commonly consist of proliferating connective tissue characterized by neoplastic growth of stellate and spindled cells within the loose, collagenous and myxoid matrix with a low number of mitotic figures (Manera et al., 1997; Pittman & Montgomery, 2015; Vergneau-Grosset et al., 2017). They are typically well-vascularized and are connected to the subcutaneous musculature (Mocellin, 2021; Song et al., 2016). The prevalence of neoplasia in teleost fishes, including laboratory model organisms, is disproportionally biased due to frequent confusion with pathogen-induced lesions (Dyková et al., 2021; Harshbarger, 1984). Therefore, it is always important to test for the presence of known pathogens in the examined animal with neoplasia. Here, we report a case of spontaneous fibromyxoma, in senescent laboratory-kept turquoise killifish Nothobranchius furzeri. Turquoise killifish are a rapidly aging species with a life expectancy of several months in the wild because they inhabit seasonally inundated pools in Southeast African savanna (Reichard & Polačik, 2018). In captivity, they live approximately 1 year; therefore, they have become a popular model organism in biogerontology and toxicology (Cellerino et al., 2016; Thoré et al., 2021).

Název v anglickém jazyce

Spontaneous exophytic tumour in Nothobranchius furzeri, an aging research model

Popis výsledku anglicky

Understanding the nature and diversity of spontaneous neoplasias in a model organism is of peculiar interest to toxicologists and biogerontologists who assess their prevalence in relation to experimental treatments (Wolf et al., 2015). In fishes, exophytic neoplasias are frequently found due to their conspicuous appearance on the body (Roberts, 2012; Vergneau-Grosset et al., 2017). Papillomas are the most common exophytic epithelial fish tumours with a predominant proliferation of epidermal cells with no to little presence of connective tissue (Roberts, 2012). Other exophytic tumours are derived from connective tissue as in fibromas, myxomas and fibromyxomas. Myxomas are soft tumours formed by immature connective tissue with extensive myxoid stroma. In contrast, a fibroma is a firm tumour derived from fibrous connective tissue (Roberts, 2012). Fibromyxomas share some traits of myxoma and fibroma and commonly consist of proliferating connective tissue characterized by neoplastic growth of stellate and spindled cells within the loose, collagenous and myxoid matrix with a low number of mitotic figures (Manera et al., 1997; Pittman & Montgomery, 2015; Vergneau-Grosset et al., 2017). They are typically well-vascularized and are connected to the subcutaneous musculature (Mocellin, 2021; Song et al., 2016). The prevalence of neoplasia in teleost fishes, including laboratory model organisms, is disproportionally biased due to frequent confusion with pathogen-induced lesions (Dyková et al., 2021; Harshbarger, 1984). Therefore, it is always important to test for the presence of known pathogens in the examined animal with neoplasia. Here, we report a case of spontaneous fibromyxoma, in senescent laboratory-kept turquoise killifish Nothobranchius furzeri. Turquoise killifish are a rapidly aging species with a life expectancy of several months in the wild because they inhabit seasonally inundated pools in Southeast African savanna (Reichard & Polačik, 2018). In captivity, they live approximately 1 year; therefore, they have become a popular model organism in biogerontology and toxicology (Cellerino et al., 2016; Thoré et al., 2021).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Fish Diseases

ISSN

0140-7775

e-ISSN

1365-2761

Svazek periodika

47

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

"e14021"

Kód UT WoS článku

001313094700001

EID výsledku v databázi Scopus

2-s2.0-85204085814