Gold nanoparticles functionalised with urea-based gemini surfactants

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F25%3AN0000084" target="_blank" >RIV/00027162:_____/25:N0000084 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0167732225017301?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0167732225017301?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.molliq.2025.128553" target="_blank" >10.1016/j.molliq.2025.128553</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gold nanoparticles functionalised with urea-based gemini surfactants

Popis výsledku v původním jazyce

The present study is focused on the synthesis gold nanoparticles (AuNPs) and investigation of their physical parameters and biological activity after functionalisation with cationic bisammonium gemini surfactants with urea groups in their alkyl chains and a variable length of polymethylene spacer in the range 2–10 methylene groups. UV-VIS spectroscopy confirmed the formation of stable gold nanodispersions with plasmon resonance peaks in the interval of wavelengths 540–560 nm at all investigated surfactant spacer length values. The region of stable gold nanodispersions covered the range of surfactant to gold molar ratio values up to 3.3. At higher molar ratio values, nanoparticle agglomeration was observed. Dynamic light scattering measurements and scanning electron microscopy confirmed the formation of AuNPs with the size between 45 and 117 nm which depended on the molar ratio and the spacer length of stabilising surfactant. Notable increase in AuNPs size was observed at the high surfactant to gold molar ratio because of nanoparticles agglomeration and instability of nanodispersions. A moderate size increase of AuNPs functionalised with urea gemini surfactant with a short spacer is observed. Positive zeta potential values between +30 and + 50 mV also indicated the formation of stable AuNPs. Cytotoxicity determination revealed the highest activity for AuNPs functionalised with urea gemini surfactant with the short spacer of 2 CH2 groups. As the surfactant spacer length increased, cytotoxicity differences between AuNPs functionalised with individual gemini surfactants became insignificant as a consequence of increasing hydrophobicity of the capping agent. However, anti-inflammatory potential of urea gemini capped AuNPs did not significantly exceed the level of standards. On the other hand, some of tested AuNPs showed chondroprotective potential. The presence of urea groups in the molecular structure of stabilising surfactants provides new opportunities of controlling the composition of AuNPs during their synthesis to receive nanoparticle systems with tailored physical parameters and interesting levels of biological activity.

Název v anglickém jazyce

Gold nanoparticles functionalised with urea-based gemini surfactants

Popis výsledku anglicky

The present study is focused on the synthesis gold nanoparticles (AuNPs) and investigation of their physical parameters and biological activity after functionalisation with cationic bisammonium gemini surfactants with urea groups in their alkyl chains and a variable length of polymethylene spacer in the range 2–10 methylene groups. UV-VIS spectroscopy confirmed the formation of stable gold nanodispersions with plasmon resonance peaks in the interval of wavelengths 540–560 nm at all investigated surfactant spacer length values. The region of stable gold nanodispersions covered the range of surfactant to gold molar ratio values up to 3.3. At higher molar ratio values, nanoparticle agglomeration was observed. Dynamic light scattering measurements and scanning electron microscopy confirmed the formation of AuNPs with the size between 45 and 117 nm which depended on the molar ratio and the spacer length of stabilising surfactant. Notable increase in AuNPs size was observed at the high surfactant to gold molar ratio because of nanoparticles agglomeration and instability of nanodispersions. A moderate size increase of AuNPs functionalised with urea gemini surfactant with a short spacer is observed. Positive zeta potential values between +30 and + 50 mV also indicated the formation of stable AuNPs. Cytotoxicity determination revealed the highest activity for AuNPs functionalised with urea gemini surfactant with the short spacer of 2 CH2 groups. As the surfactant spacer length increased, cytotoxicity differences between AuNPs functionalised with individual gemini surfactants became insignificant as a consequence of increasing hydrophobicity of the capping agent. However, anti-inflammatory potential of urea gemini capped AuNPs did not significantly exceed the level of standards. On the other hand, some of tested AuNPs showed chondroprotective potential. The presence of urea groups in the molecular structure of stabilising surfactants provides new opportunities of controlling the composition of AuNPs during their synthesis to receive nanoparticle systems with tailored physical parameters and interesting levels of biological activity.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Molecular Liquids

ISSN

0167-7322

e-ISSN

1873-3166

Svazek periodika

473

Číslo periodika v rámci svazku

Part C

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

—

Kód UT WoS článku

999

EID výsledku v databázi Scopus

2-s2.0-105016315422