Interaction of common sequence variants and selected risk factors in determination of HDL cholesterol levels.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F10%3A7161" target="_blank" >RIV/00064165:_____/10:7161 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/10:00002325 RIV/00216208:11110/10:7161

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Interaction of common sequence variants and selected risk factors in determination of HDL cholesterol levels.

Popis výsledku v původním jazyce

The aim of our study was to assess the association of common sequence variants, and selected interactions, with HDL-c plasma levels. We analysed 743 individuals (340 men and 403 women) with high mean triglyceride and LDL-c levels. The association of fivepolymorphic sites (ABCA1 g.1051G>A, APOA1 g.-75G>A, CETP g.-629C>A, HNF1A g.102A>C, and LIPG g.584C>T), apoE isoforms and selected interactions with HDL-c levels were evaluated using linear regression models. After adjusting for triglycerides, sex, andBMI the only genotype with a statistically significant effect on HDL-c levels (p-value=0.004) was the CETP promoter variant. Further, linear regression model with interactions included indicated possible interplay between APOA1 genotype and menopause (p-value=0.002) and ABCA1 and APOE isoforms (p-value=0.017) on HDL-c plasma concentration. Our study indicated that not only the CETP variant but also apoE isoforms and menopause could operate as potent modulators of HDL-c concentrations.

Název v anglickém jazyce

Interaction of common sequence variants and selected risk factors in determination of HDL cholesterol levels.

Popis výsledku anglicky

The aim of our study was to assess the association of common sequence variants, and selected interactions, with HDL-c plasma levels. We analysed 743 individuals (340 men and 403 women) with high mean triglyceride and LDL-c levels. The association of fivepolymorphic sites (ABCA1 g.1051G>A, APOA1 g.-75G>A, CETP g.-629C>A, HNF1A g.102A>C, and LIPG g.584C>T), apoE isoforms and selected interactions with HDL-c levels were evaluated using linear regression models. After adjusting for triglycerides, sex, andBMI the only genotype with a statistically significant effect on HDL-c levels (p-value=0.004) was the CETP promoter variant. Further, linear regression model with interactions included indicated possible interplay between APOA1 genotype and menopause (p-value=0.002) and ABCA1 and APOE isoforms (p-value=0.017) on HDL-c plasma concentration. Our study indicated that not only the CETP variant but also apoE isoforms and menopause could operate as potent modulators of HDL-c concentrations.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/NS10327" target="_blank" >NS10327: Komplexní genetická analýza u pacientů s mentální retardací a dysmorfiemi - stanovení vhodného diagnostického postupu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Biochemistry

ISSN

0009-9120

e-ISSN

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Svazek periodika

43

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

000278161200009

EID výsledku v databázi Scopus

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