High-risk human papillomavirus DNA in paraaortic lymph nodes in advanced stages of cervical carcinoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F11%3A10160" target="_blank" >RIV/00064165:_____/11:10160 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/11:10160

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jcv.2010.09.020" target="_blank" >http://dx.doi.org/10.1016/j.jcv.2010.09.020</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

High-risk human papillomavirus DNA in paraaortic lymph nodes in advanced stages of cervical carcinoma

Popis výsledku v původním jazyce

Background: Paraaortic lymph nodes represent the second level in the lymphatic spread of cervical cancer. Recent studies have confirmed the association of HPV DNA in pelvic lymph nodes in early-stage disease with metastatic involvement and a less favourable prognosis. Objective: The aim of our study was to detect 13 high-risk genotypes of HPV in paraaortic nodes harvested from patients with FIGO IB2-IIIB tumours and correlate findings with histopathology. Study design: The study involved patients with advanced cervical cancer who had undergone low paraaortic lymphadenectomy. The cytobrush technique was used for perioperative sample collection from the tumour and fresh lymphatic tissue. Patients with non-HPV related cancers were used as a control group.Results: The study involved 24 cervical cancer patients. High-risk HPV DNA was found in the primary tumour of all cases and in PALN in 16 (67%) cases. The most frequent genotype was HPV 16, both in the tumour and in the paraaortic lymph

Název v anglickém jazyce

High-risk human papillomavirus DNA in paraaortic lymph nodes in advanced stages of cervical carcinoma

Popis výsledku anglicky

Background: Paraaortic lymph nodes represent the second level in the lymphatic spread of cervical cancer. Recent studies have confirmed the association of HPV DNA in pelvic lymph nodes in early-stage disease with metastatic involvement and a less favourable prognosis. Objective: The aim of our study was to detect 13 high-risk genotypes of HPV in paraaortic nodes harvested from patients with FIGO IB2-IIIB tumours and correlate findings with histopathology. Study design: The study involved patients with advanced cervical cancer who had undergone low paraaortic lymphadenectomy. The cytobrush technique was used for perioperative sample collection from the tumour and fresh lymphatic tissue. Patients with non-HPV related cancers were used as a control group.Results: The study involved 24 cervical cancer patients. High-risk HPV DNA was found in the primary tumour of all cases and in PALN in 16 (67%) cases. The most frequent genotype was HPV 16, both in the tumour and in the paraaortic lymph

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

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Projekt

<a href="/cs/project/NS10037" target="_blank" >NS10037: Detekce subklinického metastatického postižení lymfatických uzlin u časných stádií karcinomu děložního hrdla pomocí vyšetření přítomnosti lidských papilomavirů.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Virology

ISSN

1386-6532

e-ISSN

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Svazek periodika

50

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

4

Strana od-do

46-49

Kód UT WoS článku

000286094300010

EID výsledku v databázi Scopus

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