Coordination conjugates of therapeutic proteins with drug carriers: A new approach for versatile advanced drug delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F11%3A9827" target="_blank" >RIV/00064165:_____/11:9827 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378050:_____/11:00372287 RIV/60461373:22340/11:43892283 RIV/00216208:11110/11:9827

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.bmcl.2011.06.101" target="_blank" >http://dx.doi.org/10.1016/j.bmcl.2011.06.101</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Coordination conjugates of therapeutic proteins with drug carriers: A new approach for versatile advanced drug delivery

Popis výsledku v původním jazyce

We present here a general system for the coordination attachment of therapeutic proteins to a drug delivery system and its application in combined therapy. Proof of concept is demonstrated by the synthesis and testing of the targeted drug delivery systemfor cytostatics, which is based on a combination of the drug carrier Zn-porphyrin-cyclodextrin conjugates and their supramolecular coordination complexes with immunoglobulins. This system can be as readily used for a variety of therapeutic and targetingproteins including PAs, MAs, lectins, and HSA. Moreover, it allows combined photodynamic therapy, cell targeted chemotherapy and immunotherapy. When tested in a mouse model with human C32 carcinoma, the therapeutic superiority of the coordination assembly nanosystem was shown in comparison with the efficacy of building blocks used for the construction of the system. (C) 2011 Elsevier Ltd. All rights reserved.

Název v anglickém jazyce

Coordination conjugates of therapeutic proteins with drug carriers: A new approach for versatile advanced drug delivery

Popis výsledku anglicky

We present here a general system for the coordination attachment of therapeutic proteins to a drug delivery system and its application in combined therapy. Proof of concept is demonstrated by the synthesis and testing of the targeted drug delivery systemfor cytostatics, which is based on a combination of the drug carrier Zn-porphyrin-cyclodextrin conjugates and their supramolecular coordination complexes with immunoglobulins. This system can be as readily used for a variety of therapeutic and targetingproteins including PAs, MAs, lectins, and HSA. Moreover, it allows combined photodynamic therapy, cell targeted chemotherapy and immunotherapy. When tested in a mouse model with human C32 carcinoma, the therapeutic superiority of the coordination assembly nanosystem was shown in comparison with the efficacy of building blocks used for the construction of the system. (C) 2011 Elsevier Ltd. All rights reserved.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bioorganic & Medicinal Chemistry Letters

ISSN

0960-894X

e-ISSN

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Svazek periodika

21

Číslo periodika v rámci svazku

18

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

5514-5520

Kód UT WoS článku

000294051800080

EID výsledku v databázi Scopus

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