Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery?
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00603449" target="_blank" >RIV/61389013:_____/25:00603449 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.tandfonline.com/doi/full/10.1080/17425247.2024.2436081" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/17425247.2024.2436081</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery?
Popis výsledku v původním jazyce
Biocompatible copolymer-based nanoparticles are gaining attention as anticancer drug delivery carriers due to their ease of production, ability to improve drug solubility, and targeted release properties. Stimuli-responsive hybrid copolymer nanoparticles, particularly those responsive to pH and reactive oxygen species (ROS), are promising for enhancing specificity in drug delivery. Examples include arylboronate ester-protected polymer amines and ferrocenylbased copolymers, which release their cargo upon ROS-triggered transformation. Coordination polymers (CPs) offer unique benefits due to their metal-organic composition, including biodegradability and potential therapeutic activity. CP-based nanoparticles, combined with radionuclides, show promise in theranostic applications, especially in delivering Auger electron emitters for targeted radiation therapy. Furthermore, ROS-responsive nanoparticles could be valuable in drug-free therapeutics, sensors, and anticancer vaccines, with their ability to interact selectively with cancerous or inflamed tissues.
Název v anglickém jazyce
Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery?
Popis výsledku anglicky
Biocompatible copolymer-based nanoparticles are gaining attention as anticancer drug delivery carriers due to their ease of production, ability to improve drug solubility, and targeted release properties. Stimuli-responsive hybrid copolymer nanoparticles, particularly those responsive to pH and reactive oxygen species (ROS), are promising for enhancing specificity in drug delivery. Examples include arylboronate ester-protected polymer amines and ferrocenylbased copolymers, which release their cargo upon ROS-triggered transformation. Coordination polymers (CPs) offer unique benefits due to their metal-organic composition, including biodegradability and potential therapeutic activity. CP-based nanoparticles, combined with radionuclides, show promise in theranostic applications, especially in delivering Auger electron emitters for targeted radiation therapy. Furthermore, ROS-responsive nanoparticles could be valuable in drug-free therapeutics, sensors, and anticancer vaccines, with their ability to interact selectively with cancerous or inflamed tissues.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
10404 - Polymer science
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2025
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů