Designing magnetic graphene oxide-polymer nanocomposites for pH-responsive passive targeting of hydrophobic anticancer drug 5-fluorouracil for breast cancer therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00637798" target="_blank" >RIV/61389013:_____/25:00637798 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0378517325007938?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0378517325007938?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijpharm.2025.125956" target="_blank" >10.1016/j.ijpharm.2025.125956</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Designing magnetic graphene oxide-polymer nanocomposites for pH-responsive passive targeting of hydrophobic anticancer drug 5-fluorouracil for breast cancer therapy

Popis výsledku v původním jazyce

In this study, we synthesized magnetic graphene oxide nanoparticles functionalized with polyvinyl alcohol (GO-PVA-Fe3O4) for effective delivery of anticancer drug and its cytotoxic potential against human breast cancer cells MDAMB. Initially, GO was synthesized using a modified Hummer’s method. Subsequently, the GO was functionalized with the biocompatible polymer PVA to enhance its aqueous stability and surface reactivity. Magnetic nanoparticles (Fe3O4) were then grafted onto the PVA-functionalized GO via a chemical co-precipitation method, resulting in the formation of a stable magnetic nanocomposite. The anticancer drug 5-fluorouracil (5FU) was loaded onto the surface of the nanocarrier by non-covalent interaction. The developed nanocomposite (GO-PVA-Fe3O4-5FU) showed high drug loading capacity of 14.17 % mg mg−1 along with pH-responsive drug release of anticancer drug 5FU. 5-FU has demonstrated around 30.40 % drug release which is about 2.5 times higher than the drug release at pH 7.4 that demonstrated improved and passive targeted drug release at cancer microenvironment. Cellular cytotoxicity of the developed nanocarrier with the drug showed biocompatibility and higher cytotoxicity against MDAMB with an IC50 value of 23.65 ± 3.72 µg/mL as compared to the nanocarrier without drug loading. Therefore, the obtained results demonstrate potential of the synthesized nanocarriers as effective platforms for drug delivery. Overall, the GO-based magnetic nanocomposites exhibited promising characteristics for passive targeted drug delivery applications, offering improved biocompatibility, pH-responsive controlled release, and suitability for prospective cancer therapeutics.

Název v anglickém jazyce

Designing magnetic graphene oxide-polymer nanocomposites for pH-responsive passive targeting of hydrophobic anticancer drug 5-fluorouracil for breast cancer therapy

Popis výsledku anglicky

In this study, we synthesized magnetic graphene oxide nanoparticles functionalized with polyvinyl alcohol (GO-PVA-Fe3O4) for effective delivery of anticancer drug and its cytotoxic potential against human breast cancer cells MDAMB. Initially, GO was synthesized using a modified Hummer’s method. Subsequently, the GO was functionalized with the biocompatible polymer PVA to enhance its aqueous stability and surface reactivity. Magnetic nanoparticles (Fe3O4) were then grafted onto the PVA-functionalized GO via a chemical co-precipitation method, resulting in the formation of a stable magnetic nanocomposite. The anticancer drug 5-fluorouracil (5FU) was loaded onto the surface of the nanocarrier by non-covalent interaction. The developed nanocomposite (GO-PVA-Fe3O4-5FU) showed high drug loading capacity of 14.17 % mg mg−1 along with pH-responsive drug release of anticancer drug 5FU. 5-FU has demonstrated around 30.40 % drug release which is about 2.5 times higher than the drug release at pH 7.4 that demonstrated improved and passive targeted drug release at cancer microenvironment. Cellular cytotoxicity of the developed nanocarrier with the drug showed biocompatibility and higher cytotoxicity against MDAMB with an IC50 value of 23.65 ± 3.72 µg/mL as compared to the nanocarrier without drug loading. Therefore, the obtained results demonstrate potential of the synthesized nanocarriers as effective platforms for drug delivery. Overall, the GO-based magnetic nanocomposites exhibited promising characteristics for passive targeted drug delivery applications, offering improved biocompatibility, pH-responsive controlled release, and suitability for prospective cancer therapeutics.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Pharmaceutics

ISSN

0378-5173

e-ISSN

1873-3476

Svazek periodika

682

Číslo periodika v rámci svazku

15 September

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

14

Strana od-do

125956

Kód UT WoS článku

001540280500001

EID výsledku v databázi Scopus

2-s2.0-105010692656