Decreased serum antioxidant capacity in patients with Wilson disease is associated with neurological symptoms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F12%3A11394" target="_blank" >RIV/00064165:_____/12:11394 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/12:11394

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s10545-011-9422-5" target="_blank" >http://dx.doi.org/10.1007/s10545-011-9422-5</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Decreased serum antioxidant capacity in patients with Wilson disease is associated with neurological symptoms

Popis výsledku v původním jazyce

Wilson disease (WD) is an inherited disorder of copper disposition caused by an ATP7B transporter gene mutation, leading to copper accumulation in predisposed tissues. In addition to a genetic predisposition, other factors are likely to contribute to itsclinical manifestation. The aim of the study was to assess whether oxidative stress affects the phenotypic manifestation of WD. In 56 patients with WD (29 men; 26 with the hepatic form, 22 with the neurologic form, and eight asymptomatic; mean age 38.5+/- 12 years), total serum antioxidant capacity (TAC) and inflammatory parameters (hs-CRP, IL-1 beta, IL-2, IL-6, IL-10, and TNF-alpha) were analyzed and related to the clinical manifestation, and mutations of the ATP7B gene. The control group for the TAC and inflammatory parameters consisted of 50 age- and gender-matched healthy individuals. WD patients had a significantly lower TAC (p < 0.00001), lower IL-10 levels (p = 0.039), as well as both higher IL-1 beta (p = 0.019) and IL-6 (p =

Název v anglickém jazyce

Decreased serum antioxidant capacity in patients with Wilson disease is associated with neurological symptoms

Popis výsledku anglicky

Wilson disease (WD) is an inherited disorder of copper disposition caused by an ATP7B transporter gene mutation, leading to copper accumulation in predisposed tissues. In addition to a genetic predisposition, other factors are likely to contribute to itsclinical manifestation. The aim of the study was to assess whether oxidative stress affects the phenotypic manifestation of WD. In 56 patients with WD (29 men; 26 with the hepatic form, 22 with the neurologic form, and eight asymptomatic; mean age 38.5+/- 12 years), total serum antioxidant capacity (TAC) and inflammatory parameters (hs-CRP, IL-1 beta, IL-2, IL-6, IL-10, and TNF-alpha) were analyzed and related to the clinical manifestation, and mutations of the ATP7B gene. The control group for the TAC and inflammatory parameters consisted of 50 age- and gender-matched healthy individuals. WD patients had a significantly lower TAC (p < 0.00001), lower IL-10 levels (p = 0.039), as well as both higher IL-1 beta (p = 0.019) and IL-6 (p =

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Inherited Metabolic Disease

ISSN

0141-8955

e-ISSN

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Svazek periodika

35

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

541-548

Kód UT WoS článku

000302492300019

EID výsledku v databázi Scopus

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