EN-RAGE (extracellular newly identified receptor for advanced glycation end-products binding protein) and mortality of long-term hemodialysis patients: A prospective observational cohort study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F12%3A12540" target="_blank" >RIV/00064165:_____/12:12540 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/12:00056335 RIV/00216208:11110/12:12540

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.clinbiochem.2012.02.014" target="_blank" >http://dx.doi.org/10.1016/j.clinbiochem.2012.02.014</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

EN-RAGE (extracellular newly identified receptor for advanced glycation end-products binding protein) and mortality of long-term hemodialysis patients: A prospective observational cohort study

Popis výsledku v původním jazyce

Objectives: EN-RAGE is extracellular newly identified receptor for advanced glycation end-products binding protein playing a role in inflammation. The aim was to test the relationship of EN-RAGE to prognosis of long-term hemodialysis patients (HD). Design and methods: This is a prospective observational cohort study in 261 HD patients followed up for five years. Laboratory parameters were measured at the beginning of the study. Results: EN-RAGE was slightly but unsignificantly increased in HD patients compared with healthy controls and correlated significantly with inflammatory markers. Univariate Cox analysis demonstrated ENRAGE as a significant predictor for mortality due to infection (HR (95%CI): 1.305 (1.063-1.602), per standard deviation, p = 0.01), but this significance disappeared in multivariate Cox analysis when CRP was included into the model. Conclusions: Our study demonstrates EN-RAGE as an inflammatory biomarker. It is related to mortality of HD patients due to infection,

Název v anglickém jazyce

EN-RAGE (extracellular newly identified receptor for advanced glycation end-products binding protein) and mortality of long-term hemodialysis patients: A prospective observational cohort study

Popis výsledku anglicky

Objectives: EN-RAGE is extracellular newly identified receptor for advanced glycation end-products binding protein playing a role in inflammation. The aim was to test the relationship of EN-RAGE to prognosis of long-term hemodialysis patients (HD). Design and methods: This is a prospective observational cohort study in 261 HD patients followed up for five years. Laboratory parameters were measured at the beginning of the study. Results: EN-RAGE was slightly but unsignificantly increased in HD patients compared with healthy controls and correlated significantly with inflammatory markers. Univariate Cox analysis demonstrated ENRAGE as a significant predictor for mortality due to infection (HR (95%CI): 1.305 (1.063-1.602), per standard deviation, p = 0.01), but this significance disappeared in multivariate Cox analysis when CRP was included into the model. Conclusions: Our study demonstrates EN-RAGE as an inflammatory biomarker. It is related to mortality of HD patients due to infection,

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/NS10043" target="_blank" >NS10043: Genetická predispozice a nové biochemické markery kardiovaskulárního rizika u pacientů s chronickým onemocněním ledvin.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Biochemistry

ISSN

0009-9120

e-ISSN

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Svazek periodika

45

Číslo periodika v rámci svazku

7-8

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

5

Strana od-do

556-560

Kód UT WoS článku

000303553300009

EID výsledku v databázi Scopus

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