Serum S100A12 (EN-RAGE) Levels in Patients with Decreased Renal Function and Subclinical Chronic Inflammatory Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9165" target="_blank" >RIV/00216208:11110/11:9165 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/11:00181727 RIV/00064165:_____/11:9165

Výsledek na webu

<a href="http://dx.doi.org/10.1159/000329291" target="_blank" >http://dx.doi.org/10.1159/000329291</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Serum S100A12 (EN-RAGE) Levels in Patients with Decreased Renal Function and Subclinical Chronic Inflammatory Disease

Popis výsledku v původním jazyce

Background: The calcium-binding protein S100A12 (EN-RAGE) causes inflammation through interaction with the multiligand receptor for advanced glycation end products (RAGE). The aim of the study was to determine S100A12 levels and describe their relationship to inflammatory markers in patients with decreased renal function. Methods: The studied group consisted of 46 patients with various degrees of chronic renal insufficiency (CHRI), 31 long-term hemodialysis (HD) patients and 24 healthy controls. S100A12and soluble RAGE were assessed immunochemically (ELISA), and routine biochemical parameters were measured. Results: S100A12 levels were not different in CHRI (166 +/- 140 ng/ml) and HD patients (127 +/- 101 ng/ml) compared to controls (126 +/- 106 ng/ml; p = 0.20, n.s.). In CHRI patients, S100A12 correlated with C-reactive protein (CRP) levels, orosomucoid, and inversely with alpha(2)-macroglobulin. In HD patients, S100A12 correlated with age, CRP, orosomucoid, fibrinogen and leukocyte

Název v anglickém jazyce

Serum S100A12 (EN-RAGE) Levels in Patients with Decreased Renal Function and Subclinical Chronic Inflammatory Disease

Popis výsledku anglicky

Background: The calcium-binding protein S100A12 (EN-RAGE) causes inflammation through interaction with the multiligand receptor for advanced glycation end products (RAGE). The aim of the study was to determine S100A12 levels and describe their relationship to inflammatory markers in patients with decreased renal function. Methods: The studied group consisted of 46 patients with various degrees of chronic renal insufficiency (CHRI), 31 long-term hemodialysis (HD) patients and 24 healthy controls. S100A12and soluble RAGE were assessed immunochemically (ELISA), and routine biochemical parameters were measured. Results: S100A12 levels were not different in CHRI (166 +/- 140 ng/ml) and HD patients (127 +/- 101 ng/ml) compared to controls (126 +/- 106 ng/ml; p = 0.20, n.s.). In CHRI patients, S100A12 correlated with C-reactive protein (CRP) levels, orosomucoid, and inversely with alpha(2)-macroglobulin. In HD patients, S100A12 correlated with age, CRP, orosomucoid, fibrinogen and leukocyte

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

<a href="/cs/project/NS10043" target="_blank" >NS10043: Genetická predispozice a nové biochemické markery kardiovaskulárního rizika u pacientů s chronickým onemocněním ledvin.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Kidney and Blood Pressure Research

ISSN

1420-4096

e-ISSN

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Svazek periodika

34

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

8

Strana od-do

457-464

Kód UT WoS článku

000297128400011

EID výsledku v databázi Scopus

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