PLASMA FREE METANEPHRINES AS DIAGNOSTIC MARKERS OF PHEOCHROMOCYTOMA

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F13%3A10210260" target="_blank" >RIV/00064165:_____/13:10210260 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/13:10210260

Výsledek na webu

<a href="http://www.chemicke-listy.cz/docs/full/2013_s3_s420-s453.pdf" target="_blank" >http://www.chemicke-listy.cz/docs/full/2013_s3_s420-s453.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

PLASMA FREE METANEPHRINES AS DIAGNOSTIC MARKERS OF PHEOCHROMOCYTOMA

Popis výsledku v původním jazyce

Quantitative determination of catecholamines and their O-methyl metabolites plays an important role in the diagnosis of pheochromocytoma (PHEO) - adrenal medulla tumour. This kind of tumour synthesizes, stocks, metabolizes and mostly secretes catecholamines. For this reason it is possible to use elevated concentrations of catecholamines and their metabolic products from plasma and urine as diagnostic markers of this tumour. Determination of metanephrines is often preferred against determination of catecholamines regarding the diagnosis of PHEO. Tumour cells produce free metanephrines continuously and irrespective of the release of catecholamines. The project aims to develop a new kit for the determination of plasma metanephrines. Solid phase extraction(SPE) was used for the pre-treatment of plasma samples. The determination was performed by high performance liquid chromatography with electrochemical detection (HPLC-ED).

Název v anglickém jazyce

PLASMA FREE METANEPHRINES AS DIAGNOSTIC MARKERS OF PHEOCHROMOCYTOMA

Popis výsledku anglicky

Quantitative determination of catecholamines and their O-methyl metabolites plays an important role in the diagnosis of pheochromocytoma (PHEO) - adrenal medulla tumour. This kind of tumour synthesizes, stocks, metabolizes and mostly secretes catecholamines. For this reason it is possible to use elevated concentrations of catecholamines and their metabolic products from plasma and urine as diagnostic markers of this tumour. Determination of metanephrines is often preferred against determination of catecholamines regarding the diagnosis of PHEO. Tumour cells produce free metanephrines continuously and irrespective of the release of catecholamines. The project aims to develop a new kit for the determination of plasma metanephrines. Solid phase extraction(SPE) was used for the pre-treatment of plasma samples. The determination was performed by high performance liquid chromatography with electrochemical detection (HPLC-ED).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

<a href="/cs/project/FR-TI4%2F331" target="_blank" >FR-TI4/331: *Vývoj kitu pro stanovení plazmatických metanefrinů</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemické listy

ISSN

0009-2770

e-ISSN

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Svazek periodika

107

Číslo periodika v rámci svazku

Supplement 3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

3

Strana od-do

"S420"-"S422"

Kód UT WoS článku

000328730800056

EID výsledku v databázi Scopus

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