The prevalence of nonalcoholic liver steatosis in patients with type 2 diabetes mellitus in the Czech Republic

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F15%3A10285526" target="_blank" >RIV/00064165:_____/15:10285526 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/15:10285526

Výsledek na webu

<a href="http://biomed.papers.upol.cz/pdfs/bio/2015/03/18.pdf" target="_blank" >http://biomed.papers.upol.cz/pdfs/bio/2015/03/18.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2014.033" target="_blank" >10.5507/bp.2014.033</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The prevalence of nonalcoholic liver steatosis in patients with type 2 diabetes mellitus in the Czech Republic

Popis výsledku v původním jazyce

Nonalcoholic fatty liver disease (NAFLD) is associated with components of the metabolic syndrome (MS) but the prevalence of NAFLD in the Czech Republic is unknown. The aim of this study was to assess the latter in patients with type 2 diabetes (DM2) and to compare the noninvasive fibrosis scores with ultrasound findings in those patients. 180 consecutive patients with DM2 (mean age 64.2 +- 9.3 years, 63% men) were examined for liver biochemistry, MS parameters and had liver ultrasound. MS was diagnosed according to the International Diabetes Federation. The diagnosis of NAFLD was based on liver ultrasound. Other aetiology of liver lesion was ruled out. Additionally, AST/ALT ratio, APRI, NAFLD fibrosis score, FIB4 and BARD scores were calculated. 93% of patients met the MS criteria, 79 % had NAFLD and 13 % had ultrasound signs of fibrosis/cirrhosis. NAFLD patients had greater weight (96.9 +- 19.3 vs 84.7 +- 14.7 kg; P = 0.003), BMI (32.6 +- 5.2 vs 29.4 +- 5.4 kg/m2; P = 0.007), waist circumference (113.8 +- 12.8 vs 107.1 +- 10.3 cm; P = 0.033), ALT (0.73 +- 0.57 vs 0.55 +- 0.53 ukat/L, P = 0.007) and triglyc- eridaemia (1.9 +- 1.4 vs 1.4 +- 1 mmol/L; P = 0.005) than patients without NAFLD. There were no significant differences in age, sex, cholesterol, fasting glycaemia or glycated haemoglobin. Of calculated scores only the NAFLD fibrosis score revealed significant differences between patients with and without ultrasound signs of fibrosis/cirrhosis (1.027 +- 2.228 vs -0.118 +- 1.402, P = 0.026). Patients with DM2 had in the majority of cases NAFLD which was related to weight, BMI, waist circumfer-ence and serum triglycerides. The validity of the liver fibrosis scoring system has to be assessed in those patients in the future.

Název v anglickém jazyce

The prevalence of nonalcoholic liver steatosis in patients with type 2 diabetes mellitus in the Czech Republic

Popis výsledku anglicky

Nonalcoholic fatty liver disease (NAFLD) is associated with components of the metabolic syndrome (MS) but the prevalence of NAFLD in the Czech Republic is unknown. The aim of this study was to assess the latter in patients with type 2 diabetes (DM2) and to compare the noninvasive fibrosis scores with ultrasound findings in those patients. 180 consecutive patients with DM2 (mean age 64.2 +- 9.3 years, 63% men) were examined for liver biochemistry, MS parameters and had liver ultrasound. MS was diagnosed according to the International Diabetes Federation. The diagnosis of NAFLD was based on liver ultrasound. Other aetiology of liver lesion was ruled out. Additionally, AST/ALT ratio, APRI, NAFLD fibrosis score, FIB4 and BARD scores were calculated. 93% of patients met the MS criteria, 79 % had NAFLD and 13 % had ultrasound signs of fibrosis/cirrhosis. NAFLD patients had greater weight (96.9 +- 19.3 vs 84.7 +- 14.7 kg; P = 0.003), BMI (32.6 +- 5.2 vs 29.4 +- 5.4 kg/m2; P = 0.007), waist circumference (113.8 +- 12.8 vs 107.1 +- 10.3 cm; P = 0.033), ALT (0.73 +- 0.57 vs 0.55 +- 0.53 ukat/L, P = 0.007) and triglyc- eridaemia (1.9 +- 1.4 vs 1.4 +- 1 mmol/L; P = 0.005) than patients without NAFLD. There were no significant differences in age, sex, cholesterol, fasting glycaemia or glycated haemoglobin. Of calculated scores only the NAFLD fibrosis score revealed significant differences between patients with and without ultrasound signs of fibrosis/cirrhosis (1.027 +- 2.228 vs -0.118 +- 1.402, P = 0.026). Patients with DM2 had in the majority of cases NAFLD which was related to weight, BMI, waist circumfer-ence and serum triglycerides. The validity of the liver fibrosis scoring system has to be assessed in those patients in the future.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

—

Projekt

<a href="/cs/project/NT11247" target="_blank" >NT11247: Úloha protektivních faktorů, oxidačního stresu a zánětlivé reakce v rozvoji nealkoholického jaterního postižení u pacientů s metabolickým syndromem a možnost ovlivnění jaterního postižení v experimentu.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

—

Svazek periodika

159

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

442-448

Kód UT WoS článku

000364948100018

EID výsledku v databázi Scopus

2-s2.0-84942856721