Non-invasive diagnostics of liver fibrosis in patients with type 2 diabetes in daily practice

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Non-invasive diagnostics of liver fibrosis in patients with type 2 diabetes in daily practice

Popis výsledku v původním jazyce

Introduction: The amount of liver fibrosis represents the most impoortant prognostic factor oin NAFLD. We aimed to assess the possibilities of non-invasive staging of liver fibrosis in difficult to examine patients. Methods: 93 consecutive patients with type 2 diabetes(DM2) with late complications were examined (basic laboratory examination, anthropometric parameters, abdominal ultrasound with poin shear wave elastography). Non invasive scores of liver fibrosis (APRI, FIB-4, BARD, NAFLD fibrosis score) were calculated. Results: We examined 93 patients (mean age 68 -10.1 years, BMI 30.1 -4.58, waist circumference 110 -11.1 cm, none patient had normal waist circumference, all had metabolic syndrome). Steatosis was present in 65 (70%) patients, elastography measurement meeting quality criteria was possible in 56 (60%) patients, borderline in 17 (18.2%), not possible in 20 (21.5%) patients. 7 patients (9.6%) reliable borderline measurable group had values in a range of advanced fibrosis/cirrhosis (F3/4). The reliability of measurement was associated with lower BMI, waist circumference and thoracic wall thickness. In the group of patients which couldn`t have been measured the non-invasive scores were of no use, because they brought controversial results. Discussion/Conclusion: Type 2 diabetic patients with late complications represent a subgroup of patient with significant prevalence of advanced liver fibrosis/cirrhosis. In a substantial amount of these patients elastography measurement is unreliable and basic non-invasive scoring systems are of no help.

Název v anglickém jazyce

Non-invasive diagnostics of liver fibrosis in patients with type 2 diabetes in daily practice

Popis výsledku anglicky

Introduction: The amount of liver fibrosis represents the most impoortant prognostic factor oin NAFLD. We aimed to assess the possibilities of non-invasive staging of liver fibrosis in difficult to examine patients. Methods: 93 consecutive patients with type 2 diabetes(DM2) with late complications were examined (basic laboratory examination, anthropometric parameters, abdominal ultrasound with poin shear wave elastography). Non invasive scores of liver fibrosis (APRI, FIB-4, BARD, NAFLD fibrosis score) were calculated. Results: We examined 93 patients (mean age 68 -10.1 years, BMI 30.1 -4.58, waist circumference 110 -11.1 cm, none patient had normal waist circumference, all had metabolic syndrome). Steatosis was present in 65 (70%) patients, elastography measurement meeting quality criteria was possible in 56 (60%) patients, borderline in 17 (18.2%), not possible in 20 (21.5%) patients. 7 patients (9.6%) reliable borderline measurable group had values in a range of advanced fibrosis/cirrhosis (F3/4). The reliability of measurement was associated with lower BMI, waist circumference and thoracic wall thickness. In the group of patients which couldn`t have been measured the non-invasive scores were of no use, because they brought controversial results. Discussion/Conclusion: Type 2 diabetic patients with late complications represent a subgroup of patient with significant prevalence of advanced liver fibrosis/cirrhosis. In a substantial amount of these patients elastography measurement is unreliable and basic non-invasive scoring systems are of no help.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů