Changes in Paraoxonase 1 activity and concentration of conjugated dienes in connection with number of metabolic syndrome components

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10324023" target="_blank" >RIV/00064165:_____/16:10324023 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/16:10324023

Výsledek na webu

<a href="http://www.cskb.cz/res/file/KBM-pdf/2016/2016-2/KBM-2-2016-Stankova-88.pdf" target="_blank" >http://www.cskb.cz/res/file/KBM-pdf/2016/2016-2/KBM-2-2016-Stankova-88.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Changes in Paraoxonase 1 activity and concentration of conjugated dienes in connection with number of metabolic syndrome components

Popis výsledku v původním jazyce

Objective: Paraoxonase 1 is an antioxidant enzyme with a variety of physiological roles - one of them is the inhibition of LDL (low-density lipoprotein) lipid peroxidation and inactivation of LDL-derived oxidized phospholipids. The aim of this study was to investigate the PON1 activity and levels of conjugated dienes in precipitated LDL (CD/LDL) in subjects, who fulfill different numbers of metabolic syndrome (MetS) criteria. Design: Cross-sectional study Settings: 4th Department of Internal Medicine, 1st Faculty of Medicine, Charles University and General University Hospital Prague Material and methods: The population under study consisted of 354 Caucasian subjects (188 females/166 males) divided into 6 groups according to the number of presented components of metabolic syndrome. All groups were age matched. The activity of paraoxonase 1 and concentration of conjugated dienes in precipitated LDL (CD/LDL) were both assessed spectrophotometrically. Results: The activity of PON1 was significantly decreased in subjects with all 5 components of MetS in comparison with those with 0 to 3 components of MetS (p < 0.05). The concentrations of CD/LDL were increased in subjects with 4 or 5 components of MetS compared to subjects with 0-3 components of MetS (p < 0.001). Conclusion: As was shown in this study, the levels of PON1 are extensively affected by the concentration of HDL-C and ApoA1. PON1 activity is depressed and CD/LDL levels are increased mainly in subjects who fulfill all five criteria of MetS.

Název v anglickém jazyce

Changes in Paraoxonase 1 activity and concentration of conjugated dienes in connection with number of metabolic syndrome components

Popis výsledku anglicky

Objective: Paraoxonase 1 is an antioxidant enzyme with a variety of physiological roles - one of them is the inhibition of LDL (low-density lipoprotein) lipid peroxidation and inactivation of LDL-derived oxidized phospholipids. The aim of this study was to investigate the PON1 activity and levels of conjugated dienes in precipitated LDL (CD/LDL) in subjects, who fulfill different numbers of metabolic syndrome (MetS) criteria. Design: Cross-sectional study Settings: 4th Department of Internal Medicine, 1st Faculty of Medicine, Charles University and General University Hospital Prague Material and methods: The population under study consisted of 354 Caucasian subjects (188 females/166 males) divided into 6 groups according to the number of presented components of metabolic syndrome. All groups were age matched. The activity of paraoxonase 1 and concentration of conjugated dienes in precipitated LDL (CD/LDL) were both assessed spectrophotometrically. Results: The activity of PON1 was significantly decreased in subjects with all 5 components of MetS in comparison with those with 0 to 3 components of MetS (p < 0.05). The concentrations of CD/LDL were increased in subjects with 4 or 5 components of MetS compared to subjects with 0-3 components of MetS (p < 0.001). Conclusion: As was shown in this study, the levels of PON1 are extensively affected by the concentration of HDL-C and ApoA1. PON1 activity is depressed and CD/LDL levels are increased mainly in subjects who fulfill all five criteria of MetS.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/NT13199" target="_blank" >NT13199: Vybrané genetické a nutriční faktory v patogeneze metabolického syndromu – význam vícenenasycených mastných kyselin</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Klinická biochemie a metabolismus

ISSN

1210-7921

e-ISSN

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Svazek periodika

24

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

88-93

Kód UT WoS článku

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EID výsledku v databázi Scopus

2-s2.0-84973402049