Altered Activities of Antioxidant Enzymes in Patients with Metabolic Syndrome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10192410" target="_blank" >RIV/00216208:11110/13:10192410 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/13:10192410

Výsledek na webu

<a href="http://dx.doi.org/10.1159/000348569" target="_blank" >http://dx.doi.org/10.1159/000348569</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000348569" target="_blank" >10.1159/000348569</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Altered Activities of Antioxidant Enzymes in Patients with Metabolic Syndrome

Popis výsledku v původním jazyce

Objective: In the pathogenesis of the metabolic syndrome (MetS), an increase of oxidative stress could play an important role which is closely linked with insulin resistance, endothelial dysfunction, and chronic inflammation. The aim of our study was toassess several parameters of the antioxidant status in MetS. Methods: 40 subjects with MetS and 40 age- and sex-matched volunteers without MetS were examined for activities of superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase 1 (GPX1), glutathione reductase (GR), para-oxonase1 (PON1), concentrations of reduced glutathione (GSH), and conjugated dienes in low-density lipoprotein (CD-LDL). Results: Subjects with MetS had higher activities of CuZnSOD (p < 0.05) and GR (p < 0.001), higher concentrations of CD-LDL (p < 0.001), lower activities of CAT (p < 0.05) and PON1 (p < 0.05), and lower concentrations of GSH (p < 0.05), as compared with controls. Activity of GPX1 was not significantly changed. Conclusions: Our result

Název v anglickém jazyce

Altered Activities of Antioxidant Enzymes in Patients with Metabolic Syndrome

Popis výsledku anglicky

Objective: In the pathogenesis of the metabolic syndrome (MetS), an increase of oxidative stress could play an important role which is closely linked with insulin resistance, endothelial dysfunction, and chronic inflammation. The aim of our study was toassess several parameters of the antioxidant status in MetS. Methods: 40 subjects with MetS and 40 age- and sex-matched volunteers without MetS were examined for activities of superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase 1 (GPX1), glutathione reductase (GR), para-oxonase1 (PON1), concentrations of reduced glutathione (GSH), and conjugated dienes in low-density lipoprotein (CD-LDL). Results: Subjects with MetS had higher activities of CuZnSOD (p < 0.05) and GR (p < 0.001), higher concentrations of CD-LDL (p < 0.001), lower activities of CAT (p < 0.05) and PON1 (p < 0.05), and lower concentrations of GSH (p < 0.05), as compared with controls. Activity of GPX1 was not significantly changed. Conclusions: Our result

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NS9769" target="_blank" >NS9769: Vyšetření antioxidační rovnováhy a některých polymorfismů paraoxonasy 1 u pacientů s různými onemocněními pankreatu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Obesity Facts

ISSN

1662-4025

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

9

Strana od-do

39-47

Kód UT WoS článku

000315772800005

EID výsledku v databázi Scopus

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