Phthalates exposure indicators determined by urinary phthalate metabolites in healthy non-obese Czech adults: FANTOM study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10326937" target="_blank" >RIV/00064165:_____/16:10326937 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/16:10326937 RIV/00216208:11140/16:10326937 RIV/00669806:_____/16:10326937 RIV/75010330:_____/16:00011467

Výsledek na webu

<a href="http://dx.doi.org/10.1080/19440049.2016.1241898" target="_blank" >http://dx.doi.org/10.1080/19440049.2016.1241898</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/19440049.2016.1241898" target="_blank" >10.1080/19440049.2016.1241898</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Phthalates exposure indicators determined by urinary phthalate metabolites in healthy non-obese Czech adults: FANTOM study

Popis výsledku v původním jazyce

It is assumed that human exposure to phthalates may be associated with adverse health effects. The indicators of urinary phthalate metabolite concentrations in healthy adults are limited. In our study the phthalate metabolites concentrations were detected from 24-hour urine collection in non-obese Czech adults (n=201). Each participant filled in an 80-item questionnaire (FANTOM-SQ 2013) regarding the outdoor and indoor sources of phthalates, the use of personal care products and the food intake sources. The concentrations of 15 phthalates metabolites were analyzed following enzymatic cleavage of the glucuronide using ultra-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UHPLC -ESI-MS/MS). The indicators of chronic or acute exposure phthalate-containing materials were identified. We have shown that higher fruit consumption was positively and significantly associated with higher level of total 15 urinary phthalates biomarkers (p-value <0.001). Regular meat consumption showed negative significant association with total 15 phthalates metabolites (p-value <0.01). The use of personal care products was significantly and positively correlated with monoethyl phthalate urine concentrations (p-value <0.05). The analysis of the dietary behavior and the personal care products use in Czech non-obese population showed to be predictable tool in the level of phthalates exposure when high fruit consumption and personal care products use are linked to higher phthalate metabolites contents in the urine. However this topic deserves more research.

Název v anglickém jazyce

Phthalates exposure indicators determined by urinary phthalate metabolites in healthy non-obese Czech adults: FANTOM study

Popis výsledku anglicky

It is assumed that human exposure to phthalates may be associated with adverse health effects. The indicators of urinary phthalate metabolite concentrations in healthy adults are limited. In our study the phthalate metabolites concentrations were detected from 24-hour urine collection in non-obese Czech adults (n=201). Each participant filled in an 80-item questionnaire (FANTOM-SQ 2013) regarding the outdoor and indoor sources of phthalates, the use of personal care products and the food intake sources. The concentrations of 15 phthalates metabolites were analyzed following enzymatic cleavage of the glucuronide using ultra-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UHPLC -ESI-MS/MS). The indicators of chronic or acute exposure phthalate-containing materials were identified. We have shown that higher fruit consumption was positively and significantly associated with higher level of total 15 urinary phthalates biomarkers (p-value <0.001). Regular meat consumption showed negative significant association with total 15 phthalates metabolites (p-value <0.01). The use of personal care products was significantly and positively correlated with monoethyl phthalate urine concentrations (p-value <0.05). The analysis of the dietary behavior and the personal care products use in Czech non-obese population showed to be predictable tool in the level of phthalates exposure when high fruit consumption and personal care products use are linked to higher phthalate metabolites contents in the urine. However this topic deserves more research.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

—

Projekt

<a href="/cs/project/NT14182" target="_blank" >NT14182: Ftaláty a estrogenní endokrinní disruptory ve vztahu k metabolickým onemocněním</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment

ISSN

1944-0049

e-ISSN

—

Svazek periodika

33

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

1817-1825

Kód UT WoS článku

000388957300007

EID výsledku v databázi Scopus

2-s2.0-84992169555