Hypernasality associated with basal ganglia dysfunction: evidence from Parkinson's disease and Huntington's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10328387" target="_blank" >RIV/00064165:_____/16:10328387 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/16:00302848 RIV/00216208:11110/16:10328387

Výsledek na webu

<a href="http://dx.doi.org/10.7717/peerj.2530" target="_blank" >http://dx.doi.org/10.7717/peerj.2530</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7717/peerj.2530" target="_blank" >10.7717/peerj.2530</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hypernasality associated with basal ganglia dysfunction: evidence from Parkinson's disease and Huntington's disease

Popis výsledku v původním jazyce

Background. Although increased nasality can originate from basal ganglia dysfunction, data regarding hypernasality in Parkinson's disease (PD) and Huntington's disease (HD) are very sparse. The aim of the current study was to analyze acoustic and perceptual correlates of velopharyngeal seal closure in 37 PD and 37 HD participants in comparison to 37 healthy control speakers. Methods. Acoustical analysis was based on sustained phonation of the vowel /i/ and perceptual analysis was based on monologue. Perceptual analysis was performed by 10 raters using The Great Ormond Street Speech Assessment '98. Acoustic parameters related to changes in a 1/3-octave band centered on '1 kHz were proposed to reflect nasality lewl and behavior through utterance. Results. Perceptual analysis showed the occurrence of mild to moderate hyyernasality in 65% of PD, 89% of HD and 22% of control speakers. Based on acoustic analyses, 27% of PD 54% of HD and 19% of control speakers showed an increased occurrence of hypernasafity. In addition, 78% of HD patients demonstrated a high occurrence of intermittent hypernasality. Further results indicated relationships between the acoustic parameter representing fluctuation of nasality and perceptual assessment (r = 0.51, p <,0.001) as well as the Unified Huntington Disease Rating Scale chorea composite subscore r = 0.42, p =0.01). Conclusions. In conclusion the acoustic assessment showed that abnormal nasality was not a common feature of PD, whereas patients with HD manifested intermittent hypernasality associated with chorea.

Název v anglickém jazyce

Hypernasality associated with basal ganglia dysfunction: evidence from Parkinson's disease and Huntington's disease

Popis výsledku anglicky

Background. Although increased nasality can originate from basal ganglia dysfunction, data regarding hypernasality in Parkinson's disease (PD) and Huntington's disease (HD) are very sparse. The aim of the current study was to analyze acoustic and perceptual correlates of velopharyngeal seal closure in 37 PD and 37 HD participants in comparison to 37 healthy control speakers. Methods. Acoustical analysis was based on sustained phonation of the vowel /i/ and perceptual analysis was based on monologue. Perceptual analysis was performed by 10 raters using The Great Ormond Street Speech Assessment '98. Acoustic parameters related to changes in a 1/3-octave band centered on '1 kHz were proposed to reflect nasality lewl and behavior through utterance. Results. Perceptual analysis showed the occurrence of mild to moderate hyyernasality in 65% of PD, 89% of HD and 22% of control speakers. Based on acoustic analyses, 27% of PD 54% of HD and 19% of control speakers showed an increased occurrence of hypernasafity. In addition, 78% of HD patients demonstrated a high occurrence of intermittent hypernasality. Further results indicated relationships between the acoustic parameter representing fluctuation of nasality and perceptual assessment (r = 0.51, p <,0.001) as well as the Unified Huntington Disease Rating Scale chorea composite subscore r = 0.42, p =0.01). Conclusions. In conclusion the acoustic assessment showed that abnormal nasality was not a common feature of PD, whereas patients with HD manifested intermittent hypernasality associated with chorea.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

<a href="/cs/project/NV15-28038A" target="_blank" >NV15-28038A: Poruchy řeči a analýza jejich mechanismů u Parkinsonovy nemoci a dalších extrapyramidových onemocnění.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PeerJ

ISSN

2167-8359

e-ISSN

—

Svazek periodika

4

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

19

Strana od-do

—

Kód UT WoS článku

000385572500007

EID výsledku v databázi Scopus

2-s2.0-84991376216