Osteopontin as a Biomarker in Liver Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10329724" target="_blank" >RIV/00064165:_____/16:10329724 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/16:10329724

Výsledek na webu

<a href="http://link.springer.com/referenceworkentry/10.1007/978-94-007-7742-2_44-1" target="_blank" >http://link.springer.com/referenceworkentry/10.1007/978-94-007-7742-2_44-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-94-007-7742-2_44-1" target="_blank" >10.1007/978-94-007-7742-2_44-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Osteopontin as a Biomarker in Liver Disease

Popis výsledku v původním jazyce

Osteopontin (OPN) is a multifunctional protein, physiologically expressed in the kidney and bone. OPN expression has been attributed to many pathological conditions including inflammation, angiogenesis, fibrosis, and carcinogenesis. OPN was found to contribute to the migration of macrophages into necrotic areas in liver tissue and to serve as a key cytokine within the extracellular matrix in the liver, contributing to fibrogenesis. OPN is also involved in the evolution and progression of various cancers, including hepatocellular carcinoma. Plasma OPN levels were found to predict liver fibrosis in various chronic liver diseases such as nonalcoholic steatohepatitis, alcoholic liver disease, and chronic viral hepatitis. OPN levels correlate significantly with the degree of fibrosis and could serve as a noninvasive biomarker of portal hypertension and as a prognostic parameter in cirrhosis.

Název v anglickém jazyce

Osteopontin as a Biomarker in Liver Disease

Popis výsledku anglicky

Osteopontin (OPN) is a multifunctional protein, physiologically expressed in the kidney and bone. OPN expression has been attributed to many pathological conditions including inflammation, angiogenesis, fibrosis, and carcinogenesis. OPN was found to contribute to the migration of macrophages into necrotic areas in liver tissue and to serve as a key cytokine within the extracellular matrix in the liver, contributing to fibrogenesis. OPN is also involved in the evolution and progression of various cancers, including hepatocellular carcinoma. Plasma OPN levels were found to predict liver fibrosis in various chronic liver diseases such as nonalcoholic steatohepatitis, alcoholic liver disease, and chronic viral hepatitis. OPN levels correlate significantly with the degree of fibrosis and could serve as a noninvasive biomarker of portal hypertension and as a prognostic parameter in cirrhosis.

Druh

C - Kapitola v odborné knize

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Biomarkers in Liver Disease

ISBN

978-94-007-7742-2

Počet stran výsledku

15

Strana od-do

1-15

Počet stran knihy

400

Název nakladatele

Springer

Místo vydání

Amsterodam

Kód UT WoS kapitoly

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