Non-invasive endothelial function assessment using digital reactive hyperaemia correlates with three-dimensional intravascular ultrasound and virtual histology-derived plaque volume and plaque phenotype

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10330105" target="_blank" >RIV/00064165:_____/16:10330105 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/16:10330105

Výsledek na webu

<a href="http://dx.doi.org/10.5603/KP.a2016.0062" target="_blank" >http://dx.doi.org/10.5603/KP.a2016.0062</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5603/KP.a2016.0062" target="_blank" >10.5603/KP.a2016.0062</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Non-invasive endothelial function assessment using digital reactive hyperaemia correlates with three-dimensional intravascular ultrasound and virtual histology-derived plaque volume and plaque phenotype

Popis výsledku v původním jazyce

Background and aim: To study relationships between endothelial dysfunction (ED) and coronary atherosclerosis derived from intravascular ultrasound (IVUS) and virtual histology (VH). Methods: Endothelial dysfunction was examined by EndoPAT system (Itamar Medical) in 56 patients who underwent IVUS and VH (Volcano corp.). Reactive hyperaemia index (RHI) < 2 was used for definition of ED. IVUS sequences were divided into 5 mm-long non-overlapping and adjacent vessel segments. Plaque phenotype was determined for each frame and 5 mm vessel segment was labeled according to highest frame score (from 0 for "no lesion" to 5 for "thin cap fibroatheroma; TCFA"). Results: IVUS-VH data were collected from 41 patients suitable for three-dimensional analysis. Patients with ED exhibited larger plaque burden than those without ED (0.46 +- 0.08 vs. 0.39 +- 0.07, p = 0.014), smaller lumen area (8.59 +- 2.19 vs. 11.90 +- 3.50, p = 0.016), higher plaque risk score (2.82 +- 1.18 vs. 1.84 +- 0.90, p = 0.012), and higher number of TCFA frames (0.36 +- 0.22 vs. 0.22 +- 0.16, p = 0.038). Relative amounts of fibrous tissue correlated positively with RHI (p = 0.034, r = 0.33). The numbers of fibroatheromas and calcified plaques correlated with RHI inversely (r = -0.34, p = 0.031 and r = -0.32, p = 0.044, respectively). Conclusions: Endothelial dysfunction correlates with severity and phenotype of coronary lesions and can contribute to non-invasive detection of individuals with higher risk of cardiovascular events.

Název v anglickém jazyce

Non-invasive endothelial function assessment using digital reactive hyperaemia correlates with three-dimensional intravascular ultrasound and virtual histology-derived plaque volume and plaque phenotype

Popis výsledku anglicky

Background and aim: To study relationships between endothelial dysfunction (ED) and coronary atherosclerosis derived from intravascular ultrasound (IVUS) and virtual histology (VH). Methods: Endothelial dysfunction was examined by EndoPAT system (Itamar Medical) in 56 patients who underwent IVUS and VH (Volcano corp.). Reactive hyperaemia index (RHI) < 2 was used for definition of ED. IVUS sequences were divided into 5 mm-long non-overlapping and adjacent vessel segments. Plaque phenotype was determined for each frame and 5 mm vessel segment was labeled according to highest frame score (from 0 for "no lesion" to 5 for "thin cap fibroatheroma; TCFA"). Results: IVUS-VH data were collected from 41 patients suitable for three-dimensional analysis. Patients with ED exhibited larger plaque burden than those without ED (0.46 +- 0.08 vs. 0.39 +- 0.07, p = 0.014), smaller lumen area (8.59 +- 2.19 vs. 11.90 +- 3.50, p = 0.016), higher plaque risk score (2.82 +- 1.18 vs. 1.84 +- 0.90, p = 0.012), and higher number of TCFA frames (0.36 +- 0.22 vs. 0.22 +- 0.16, p = 0.038). Relative amounts of fibrous tissue correlated positively with RHI (p = 0.034, r = 0.33). The numbers of fibroatheromas and calcified plaques correlated with RHI inversely (r = -0.34, p = 0.031 and r = -0.32, p = 0.044, respectively). Conclusions: Endothelial dysfunction correlates with severity and phenotype of coronary lesions and can contribute to non-invasive detection of individuals with higher risk of cardiovascular events.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

<a href="/cs/project/LH12053" target="_blank" >LH12053: Predikce rozsahu a rizikovosti koronárního postižení a jejich změn při hypolipidemické terapii na základě neinvazivních vyšetření</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Kardiologia Polska

ISSN

0022-9032

e-ISSN

—

Svazek periodika

74

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

7

Strana od-do

1485-1491

Kód UT WoS článku

000393078300004

EID výsledku v databázi Scopus

2-s2.0-85008703762