Phenotypic characterization of oral mucosa: what is normal?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F17%3A10364649" target="_blank" >RIV/00064165:_____/17:10364649 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/17:10364649

Výsledek na webu

<a href="http://dx.doi.org/10.1111/jop.12556" target="_blank" >http://dx.doi.org/10.1111/jop.12556</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jop.12556" target="_blank" >10.1111/jop.12556</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Phenotypic characterization of oral mucosa: what is normal?

Popis výsledku v původním jazyce

BACKGROUND: Knowledge of the phenotypic pattern of oral squamous epithelium is important in the histopathologic evaluation of lesions including cancer. The literature on normal epithelium is controversial as the phenotype has not been evaluated in samples from completely healthy tissue donors without a history of tobacco and alcohol exposure. METHODS: In this study, we evaluated normal upper lip fornix and gingival mucosa from carefully selected young healthy donors without a history of smoking and alcohol exposure, and keratin types 8, 10, 14, and 17, filaggrin, and Ki67 were investigated in these donors. The results were compared with profile of epithelium from leukoplakia. RESULTS: The results demonstrated that the phenotypic patterns of gingiva and upper lip fornix mucosa were different. Surprisingly, a high proportion of gingival samples exhibited keratin 8 and a suprabasal signal for keratin 14. These patterns were compared with that of human oral leukoplakia, and some phenotypic similarities were noted. CONCLUSIONS: These results demonstrated oral epithelium phenotypic plasticity based on functional requirements of the microenvironment, which can be used in diagnosis.

Název v anglickém jazyce

Phenotypic characterization of oral mucosa: what is normal?

Popis výsledku anglicky

BACKGROUND: Knowledge of the phenotypic pattern of oral squamous epithelium is important in the histopathologic evaluation of lesions including cancer. The literature on normal epithelium is controversial as the phenotype has not been evaluated in samples from completely healthy tissue donors without a history of tobacco and alcohol exposure. METHODS: In this study, we evaluated normal upper lip fornix and gingival mucosa from carefully selected young healthy donors without a history of smoking and alcohol exposure, and keratin types 8, 10, 14, and 17, filaggrin, and Ki67 were investigated in these donors. The results were compared with profile of epithelium from leukoplakia. RESULTS: The results demonstrated that the phenotypic patterns of gingiva and upper lip fornix mucosa were different. Surprisingly, a high proportion of gingival samples exhibited keratin 8 and a suprabasal signal for keratin 14. These patterns were compared with that of human oral leukoplakia, and some phenotypic similarities were noted. CONCLUSIONS: These results demonstrated oral epithelium phenotypic plasticity based on functional requirements of the microenvironment, which can be used in diagnosis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30106 - Anatomy and morphology (plant science to be 1.6)

Projekt

<a href="/cs/project/NV15-28933A" target="_blank" >NV15-28933A: Nádorové mikroprostředí karcinomů hlavy a krku: prognostický význam produkce mezibuněčné hmoty nádorově asociovanými fibroblasty</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Oral Pathology and Medicine

ISSN

0904-2512

e-ISSN

—

Svazek periodika

46

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

DK - Dánské království

Počet stran výsledku

6

Strana od-do

834-839

Kód UT WoS článku

000412303500027

EID výsledku v databázi Scopus

2-s2.0-85013646529