Cognitive clinico-radiological paradox in early stages of multiple sclerosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F18%3A10368394" target="_blank" >RIV/00064165:_____/18:10368394 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/18:10368394 RIV/61384399:31140/18:00051617

Výsledek na webu

<a href="http://dx.doi.org/10.1002/acn3.512" target="_blank" >http://dx.doi.org/10.1002/acn3.512</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/acn3.512" target="_blank" >10.1002/acn3.512</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cognitive clinico-radiological paradox in early stages of multiple sclerosis

Popis výsledku v původním jazyce

Objective: To investigate whether the strength of the association between magnetic resonance imaging (MRI) metrics and cognitive outcomes differs between various multiple sclerosis subpopulations. Methods: A total of 1052 patients were included in this large cross-sectional study. Brain MRI (T1 and T2 lesion volume and brain parenchymal fraction) and neuropsychological assessment (Brief International Cognitive Assessment for Multiple Sclerosis and Paced Auditory Serial Addition Test) were performed. Results: Weak correlations between cognitive domains and MRI measures were observed in younger patients (age&lt;=30 years; absolute Spearman&apos;s rho = 0.05-0.21), with short disease duration (&lt;2 years; rho = 0.01-0.21), low Expanded Disability Status Scale [EDSS] (&lt;=1.5; rho = 0.08-0.18), low T2 lesion volume (lowest quartile; &lt;0.59 mL; rho = 0.01-0.20), and high brain parenchymal fraction (highest quartile; &gt;86.66; rho = 0.01-0.16). Stronger correlations between cognitive domains and MRI measures were observed in older patients (age&gt;50 years; rho = 0.24-0.50), with longer disease duration (&gt;15 years; rho = 0.26-0.53), higher EDSS (&gt;=5.0; rho = 0.23-0.39), greater T2 lesion volume (highest quartile; &gt;5.33 mL; rho = 0.16-0.32), and lower brain parenchymal fraction (lowest quartile; &lt;83.71; rho = 0.13-0.46). The majority of these observed results were confirmed by significant interactions (P &lt;= 0.01) using continuous variables. Interpretation: The association between structural brain damage and functional cognitive impairment is substantially weaker in multiple sclerosis patients with a low disease burden. Therefore, disease stage should be taken into consideration when interpreting associations between structural and cognitive measures in clinical trials, research studies, and clinical practice.

Název v anglickém jazyce

Cognitive clinico-radiological paradox in early stages of multiple sclerosis

Popis výsledku anglicky

Objective: To investigate whether the strength of the association between magnetic resonance imaging (MRI) metrics and cognitive outcomes differs between various multiple sclerosis subpopulations. Methods: A total of 1052 patients were included in this large cross-sectional study. Brain MRI (T1 and T2 lesion volume and brain parenchymal fraction) and neuropsychological assessment (Brief International Cognitive Assessment for Multiple Sclerosis and Paced Auditory Serial Addition Test) were performed. Results: Weak correlations between cognitive domains and MRI measures were observed in younger patients (age&lt;=30 years; absolute Spearman&apos;s rho = 0.05-0.21), with short disease duration (&lt;2 years; rho = 0.01-0.21), low Expanded Disability Status Scale [EDSS] (&lt;=1.5; rho = 0.08-0.18), low T2 lesion volume (lowest quartile; &lt;0.59 mL; rho = 0.01-0.20), and high brain parenchymal fraction (highest quartile; &gt;86.66; rho = 0.01-0.16). Stronger correlations between cognitive domains and MRI measures were observed in older patients (age&gt;50 years; rho = 0.24-0.50), with longer disease duration (&gt;15 years; rho = 0.26-0.53), higher EDSS (&gt;=5.0; rho = 0.23-0.39), greater T2 lesion volume (highest quartile; &gt;5.33 mL; rho = 0.16-0.32), and lower brain parenchymal fraction (lowest quartile; &lt;83.71; rho = 0.13-0.46). The majority of these observed results were confirmed by significant interactions (P &lt;= 0.01) using continuous variables. Interpretation: The association between structural brain damage and functional cognitive impairment is substantially weaker in multiple sclerosis patients with a low disease burden. Therefore, disease stage should be taken into consideration when interpreting associations between structural and cognitive measures in clinical trials, research studies, and clinical practice.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/GA16-03322S" target="_blank" >GA16-03322S: Objasnění mechanismů rozvoje poruch řeči a hlasu u roztroušené sklerózy s využitím nových metod objektivní akustické analýzy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Annals of Clinical and Translational Neurology [online]

ISSN

2328-9503

e-ISSN

—

Svazek periodika

5

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

81-91

Kód UT WoS článku

000422664400008

EID výsledku v databázi Scopus

2-s2.0-85037991648