Slowed articulation rate is associated with information processing speed decline in multiple sclerosis: A pilot study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10395408" target="_blank" >RIV/00064165:_____/19:10395408 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/19:00332166 RIV/00216208:11110/19:10395408

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Q5_GhBEQgT" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Q5_GhBEQgT</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jocn.2019.04.018" target="_blank" >10.1016/j.jocn.2019.04.018</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Slowed articulation rate is associated with information processing speed decline in multiple sclerosis: A pilot study

Popis výsledku v původním jazyce

Background: Impairment of cognition and speech are common in multiple sclerosis (MS) patients, but their relationship is not well understood. Objective: To describe the relationship between articulation rate characteristics and processing speed and to investigate the potential role of objective speech analysis for the detection of cognitive decline in MS. Methods: A total of 122 patients with clinically definite MS were included in this cross-sectional pilot study. Patients underwent three speaking tasks (oral diadochokinesis, reading text and monologue) and assessment of processing speed (Symbol Digit Modalities Test [SDMT], Paced Auditory Serial Addition Test-3 s [PASAT-3]). Association between articulation rate and cognition was analyzed using linear regression analysis. We estimated the area under the receiver operating characteristics curves (AUC) to evaluate the predictive accuracy of articulation rate measures for the detection of abnormal processing speed. Results: We observed an association between articulation rate and cognitive measures (rho = 0.45-0.58; p &lt; 0.001). Faster reading speed by one word per second was associated with an 18.7 point (95% confidence interval ICI] 14.9-22.5) increase of the SDMT score and 14.7 (95% CI 8.9-20.4) point increase of PASAT-3 score (both p &lt; 0.001). AUC values of articulation rate characteristics for the identification of processing speed impairment ranged between 0.67 and 0.79. Using a cutoff of 3.10 in reading speed, we were able to identify impairment in both the SDMT and PASAT-3 with 91% sensitivity and 54% specificity. Conclusion: Slowed articulation rate is strongly associated with processing speed decline. Objective quantitative speech analysis identified patients with abnormal cognitive performance.

Název v anglickém jazyce

Slowed articulation rate is associated with information processing speed decline in multiple sclerosis: A pilot study

Popis výsledku anglicky

Background: Impairment of cognition and speech are common in multiple sclerosis (MS) patients, but their relationship is not well understood. Objective: To describe the relationship between articulation rate characteristics and processing speed and to investigate the potential role of objective speech analysis for the detection of cognitive decline in MS. Methods: A total of 122 patients with clinically definite MS were included in this cross-sectional pilot study. Patients underwent three speaking tasks (oral diadochokinesis, reading text and monologue) and assessment of processing speed (Symbol Digit Modalities Test [SDMT], Paced Auditory Serial Addition Test-3 s [PASAT-3]). Association between articulation rate and cognition was analyzed using linear regression analysis. We estimated the area under the receiver operating characteristics curves (AUC) to evaluate the predictive accuracy of articulation rate measures for the detection of abnormal processing speed. Results: We observed an association between articulation rate and cognitive measures (rho = 0.45-0.58; p &lt; 0.001). Faster reading speed by one word per second was associated with an 18.7 point (95% confidence interval ICI] 14.9-22.5) increase of the SDMT score and 14.7 (95% CI 8.9-20.4) point increase of PASAT-3 score (both p &lt; 0.001). AUC values of articulation rate characteristics for the identification of processing speed impairment ranged between 0.67 and 0.79. Using a cutoff of 3.10 in reading speed, we were able to identify impairment in both the SDMT and PASAT-3 with 91% sensitivity and 54% specificity. Conclusion: Slowed articulation rate is strongly associated with processing speed decline. Objective quantitative speech analysis identified patients with abnormal cognitive performance.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/GA16-03322S" target="_blank" >GA16-03322S: Objasnění mechanismů rozvoje poruch řeči a hlasu u roztroušené sklerózy s využitím nových metod objektivní akustické analýzy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Neuroscience

ISSN

0967-5868

e-ISSN

—

Svazek periodika

65

Číslo periodika v rámci svazku

July

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

28-33

Kód UT WoS článku

000472706000006

EID výsledku v databázi Scopus

2-s2.0-85065065050