Thyroid nodules and thyroid cancer in women with positive thyroid screening in pregnancy: a double-centric, retrospective, cohort study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F22%3A10445124" target="_blank" >RIV/00064165:_____/22:10445124 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/22:10445124 RIV/00216208:11150/22:10445124 RIV/00179906:_____/22:10445124

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=IxfrtItbQ9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=IxfrtItbQ9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1530/ETJ-21-0011" target="_blank" >10.1530/ETJ-21-0011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Thyroid nodules and thyroid cancer in women with positive thyroid screening in pregnancy: a double-centric, retrospective, cohort study

Popis výsledku v původním jazyce

Objective: Thyroid nodules are a common finding in the general population. The primary aim of the study was to determine the prevalence of thyroid nodules and cancer found by ultrasound (US) in women who underwent screening for thyroid dysfunction during pregnancy. Design: A double-centric, retrospective, cohort study. Patients and methods: We searched through medical records, including thyroid ultrasonography, of pregnant women who were positively screened for thyroid disorders (using thyroid-stimulating hormone and thyroid antibodies) from an unselected population (&apos;universal screening group&apos;, n = 690) and of women who underwent the testing based on the presence of clinical risk factors defined by American Thyroid Association (&apos;case-finding group&apos;, n = 249). Results: Prevalence of benign and malignant thyroid nodules was lower in the &apos;universal screening group&apos; than in the &apos;case-finding group&apos; (9.9% vs 17.7%, P=0.002, and 0.9% vs 7.2%, P &lt; 0.001, respectively). Consistently, the thyroid cancer rate was lower among the nodules in the &apos;universal screening group&apos; than in the &apos;case-finding group&apos; (8.1% vs 29.0%, P=0.003). Ultrasound EU-TIRADS (European Thyroid Imaging and Reporting Data System) category &gt;= 4 had a 95.8% sensitivity for thyroid cancer. In palpable nodules, the prevalence of cancer was significantly higher than in the non-palpable ones (44.0% vs 2.2%, P &lt; 0.001). In a multivariate regression analysis, thyroid nodules were associated with a history of infertility and parity. Conclusions: Compared to the data from cancer registries, universal screening allowed detecting thyroid cancer in pregnancy three to five times more frequently, but the cancer rate among nodules (8.1%) did not differ from the common population. US had very good sensitivity for thyroid cancer in pregnancy.

Název v anglickém jazyce

Thyroid nodules and thyroid cancer in women with positive thyroid screening in pregnancy: a double-centric, retrospective, cohort study

Popis výsledku anglicky

Objective: Thyroid nodules are a common finding in the general population. The primary aim of the study was to determine the prevalence of thyroid nodules and cancer found by ultrasound (US) in women who underwent screening for thyroid dysfunction during pregnancy. Design: A double-centric, retrospective, cohort study. Patients and methods: We searched through medical records, including thyroid ultrasonography, of pregnant women who were positively screened for thyroid disorders (using thyroid-stimulating hormone and thyroid antibodies) from an unselected population (&apos;universal screening group&apos;, n = 690) and of women who underwent the testing based on the presence of clinical risk factors defined by American Thyroid Association (&apos;case-finding group&apos;, n = 249). Results: Prevalence of benign and malignant thyroid nodules was lower in the &apos;universal screening group&apos; than in the &apos;case-finding group&apos; (9.9% vs 17.7%, P=0.002, and 0.9% vs 7.2%, P &lt; 0.001, respectively). Consistently, the thyroid cancer rate was lower among the nodules in the &apos;universal screening group&apos; than in the &apos;case-finding group&apos; (8.1% vs 29.0%, P=0.003). Ultrasound EU-TIRADS (European Thyroid Imaging and Reporting Data System) category &gt;= 4 had a 95.8% sensitivity for thyroid cancer. In palpable nodules, the prevalence of cancer was significantly higher than in the non-palpable ones (44.0% vs 2.2%, P &lt; 0.001). In a multivariate regression analysis, thyroid nodules were associated with a history of infertility and parity. Conclusions: Compared to the data from cancer registries, universal screening allowed detecting thyroid cancer in pregnancy three to five times more frequently, but the cancer rate among nodules (8.1%) did not differ from the common population. US had very good sensitivity for thyroid cancer in pregnancy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Thyroid Journal

ISSN

2235-0640

e-ISSN

2235-0802

Svazek periodika

11

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

9

Strana od-do

e210011

Kód UT WoS článku

000808463200011

EID výsledku v databázi Scopus

—