Relation of prediabetes and type 2 diabetes mellitus to thyroid cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920433" target="_blank" >RIV/00216208:11120/20:43920433 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023761:_____/20:N0000006 RIV/00064173:_____/20:N0000044 RIV/00023001:_____/20:00080012

Výsledek na webu

<a href="https://doi.org/10.1530/EC-20-0180" target="_blank" >https://doi.org/10.1530/EC-20-0180</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1530/EC-20-0180" target="_blank" >10.1530/EC-20-0180</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Relation of prediabetes and type 2 diabetes mellitus to thyroid cancer

Popis výsledku v původním jazyce

Objective: Patients with type 2 diabetes (T2DM) generally experience a higher incidence of cancer. However, the association between T2DM and thyroid cancer is inconclusive. Methods: Case-control prospective study, where 722 patients were screened for T2DM and prediabetes (PDM) and underwent thyroid ultrasound and biochemical tests. The patients were assigned to groups of PDM (n = 55), T2DM (n = 79) or a non-diabetes group (NDM) (n = 588). Fine-needle aspiration biopsy was carried out in 263 patients. Histological examinations were done for 109 patients after surgery, with findings of 52 benign (BS) and 57 malignant tumors (MS). Results: Thirty-three percent of patients with T2DM and especially PDM were newly diagnosed by our screening: 6.5% with T2DM and 72% with PDM, re spectively. The percentage of thyroid cancers did not significantly differ between the groups (chi(2) test = 0.461; P = 0.794). Relevant positive thyroid predictors for T2DM (t-statistic = 25.87; P &lt; 0.01) and PDM (21.69; P &lt; 0.01) contrary to NDM (-26.9; P &lt; 0.01) were thyroid volume (4.79; P &lt; 0.01), thyroid nodule volume (3.25; P &lt; 0.01) and multinodular thyroid gland (4.83; P &lt; 0.01), while negative relevant predictors included the occurrence of autoimmune thyroid disease (AITD) (-2.01; P &lt; 0.05). Conclusion: In general, we did not observe an increased risk for thyroid cancer in the diabetic and prediabetic groups in comparison to controls, in spite of well-established increased risk for other malignancies. Structural and benign changes such as larger and multinodular thyroid glands, in comparison to autoimmune thyroid disease, are present more often in diabetics.

Název v anglickém jazyce

Relation of prediabetes and type 2 diabetes mellitus to thyroid cancer

Popis výsledku anglicky

Objective: Patients with type 2 diabetes (T2DM) generally experience a higher incidence of cancer. However, the association between T2DM and thyroid cancer is inconclusive. Methods: Case-control prospective study, where 722 patients were screened for T2DM and prediabetes (PDM) and underwent thyroid ultrasound and biochemical tests. The patients were assigned to groups of PDM (n = 55), T2DM (n = 79) or a non-diabetes group (NDM) (n = 588). Fine-needle aspiration biopsy was carried out in 263 patients. Histological examinations were done for 109 patients after surgery, with findings of 52 benign (BS) and 57 malignant tumors (MS). Results: Thirty-three percent of patients with T2DM and especially PDM were newly diagnosed by our screening: 6.5% with T2DM and 72% with PDM, re spectively. The percentage of thyroid cancers did not significantly differ between the groups (chi(2) test = 0.461; P = 0.794). Relevant positive thyroid predictors for T2DM (t-statistic = 25.87; P &lt; 0.01) and PDM (21.69; P &lt; 0.01) contrary to NDM (-26.9; P &lt; 0.01) were thyroid volume (4.79; P &lt; 0.01), thyroid nodule volume (3.25; P &lt; 0.01) and multinodular thyroid gland (4.83; P &lt; 0.01), while negative relevant predictors included the occurrence of autoimmune thyroid disease (AITD) (-2.01; P &lt; 0.05). Conclusion: In general, we did not observe an increased risk for thyroid cancer in the diabetic and prediabetic groups in comparison to controls, in spite of well-established increased risk for other malignancies. Structural and benign changes such as larger and multinodular thyroid glands, in comparison to autoimmune thyroid disease, are present more often in diabetics.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Endocrine Connections

ISSN

2049-3614

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

607-616

Kód UT WoS článku

000560003100006

EID výsledku v databázi Scopus

2-s2.0-85090740944