Skin autofluorescence corresponds to microvascular reactivity in diabetes mellitus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F22%3A10445345" target="_blank" >RIV/00064165:_____/22:10445345 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/22:10445345

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=OhD2bVAI8n" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=OhD2bVAI8n</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jdiacomp.2022.108206" target="_blank" >10.1016/j.jdiacomp.2022.108206</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Skin autofluorescence corresponds to microvascular reactivity in diabetes mellitus

Popis výsledku v původním jazyce

Advanced glycation accelerated by chronic hyperglycaemia contributes to the development of diabetic vascular complications throughout several mechanisms. One of these mechanisms is supposed to be impaired microvascular reactivity, that precedes significant vascular changes. The aim of this study was to find an association between advanced glycation, the soluble receptor for AGEs (sRAGE), and microvascular reactivity (MVR) in diabetes. Skin autofluorescence (SAF), which reflects advanced glycation, was assessed by AGE-Reader, MVR was measured by laser Doppler fluxmetry and evaluated together with sRAGE in 43 patients with diabetes (25 Type 1 and 18 Type 2) and 26 healthy controls of comparable age. SAF was significantly higher in patients with diabetes compared to controls (2.4 &amp; PLUSMN; 0.5 vs. 2.0 &amp; PLUSMN; 0.5 AU; p &lt; 0.01). Patients with diabetes with SAF &gt; 2.3 AU presented significantly worse MVR in both post-occlusive reactive hyperaemia (PORH) on the finger and forearm, and thermal hyperaemia (TH), compared to patients with SAF &lt; 2.3 AU. SAF was age dependent in both diabetes (r = 0.41, p &lt; 0.01) and controls (r = 0.45, p &lt; 0.05). There was no association between SAF and diabetes control expressed by glycated haemoglobin. A significant relationship was observed between SAF and sRAGE in diabetes (r = 0.56, p &lt; 0.001), but not in controls. A significant inverse association was found between SAF and MVR on the forearm in diabetes (PORH: r = -0.42, p &lt; 0.01; TH: r = -0.46, p &lt; 0.005). Both advanced glycation expressed by higher SAF or sRAGE and impaired MVR are involved in the pathogenesis of vascular complications in diabetes, and we confirm a strong interplay of these processes in this scenario.

Název v anglickém jazyce

Skin autofluorescence corresponds to microvascular reactivity in diabetes mellitus

Popis výsledku anglicky

Advanced glycation accelerated by chronic hyperglycaemia contributes to the development of diabetic vascular complications throughout several mechanisms. One of these mechanisms is supposed to be impaired microvascular reactivity, that precedes significant vascular changes. The aim of this study was to find an association between advanced glycation, the soluble receptor for AGEs (sRAGE), and microvascular reactivity (MVR) in diabetes. Skin autofluorescence (SAF), which reflects advanced glycation, was assessed by AGE-Reader, MVR was measured by laser Doppler fluxmetry and evaluated together with sRAGE in 43 patients with diabetes (25 Type 1 and 18 Type 2) and 26 healthy controls of comparable age. SAF was significantly higher in patients with diabetes compared to controls (2.4 &amp; PLUSMN; 0.5 vs. 2.0 &amp; PLUSMN; 0.5 AU; p &lt; 0.01). Patients with diabetes with SAF &gt; 2.3 AU presented significantly worse MVR in both post-occlusive reactive hyperaemia (PORH) on the finger and forearm, and thermal hyperaemia (TH), compared to patients with SAF &lt; 2.3 AU. SAF was age dependent in both diabetes (r = 0.41, p &lt; 0.01) and controls (r = 0.45, p &lt; 0.05). There was no association between SAF and diabetes control expressed by glycated haemoglobin. A significant relationship was observed between SAF and sRAGE in diabetes (r = 0.56, p &lt; 0.001), but not in controls. A significant inverse association was found between SAF and MVR on the forearm in diabetes (PORH: r = -0.42, p &lt; 0.01; TH: r = -0.46, p &lt; 0.005). Both advanced glycation expressed by higher SAF or sRAGE and impaired MVR are involved in the pathogenesis of vascular complications in diabetes, and we confirm a strong interplay of these processes in this scenario.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/NV17-31796A" target="_blank" >NV17-31796A: Tkáňová hypoxie u pacientů s chronickým onemocněním ledvin – metabolické a hemodynamické souvislosti</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Diabetes and its Complications

ISSN

1056-8727

e-ISSN

1873-460X

Svazek periodika

36

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

108206

Kód UT WoS článku

000822113100006

EID výsledku v databázi Scopus

2-s2.0-85133144365