Clinical and Prognostic Implications of Electrocardiography and Holter Monitoring Findings in Patients with Light Chain Cardiac Amyloidosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F25%3A10498229" target="_blank" >RIV/00064165:_____/25:10498229 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10498229

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=XA4jWa3YNX" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=XA4jWa3YNX</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s44411-024-00013-4" target="_blank" >10.1007/s44411-024-00013-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Clinical and Prognostic Implications of Electrocardiography and Holter Monitoring Findings in Patients with Light Chain Cardiac Amyloidosis

Popis výsledku v původním jazyce

Background: Cardiac involvement in light chain amyloidosis (AL-CA) represents an infiltrative heart disease. The aim of the study was to recognize differences between patients suffering from light chain amyloidosis with and without cardiac involvement in 12-lead electrocardiography (ECG) and 24-h Holter ECG monitoring. Methods: We prospectively analyzed data in 39 (median 66 [IQR 62;71] years, 62% males) consecutive patients with AL amyloidosis. Results: Out of all patients, AL-CA was confirmed in 26 (67%) subjects. All patients with AL-CA manifested at least one pathology ECG, which contrasted with a low prevalence of abnormal ECG findings in patients without cardiac involvement (54%), p &lt; 0.001. Abnormal Holter ECG findings were documented in 77% and 62% of patients with and without AL-CA. During 19 (7;59) months of follow-up, 19 (73%) patients with AL-CA died. The mortality rate was significantly lower in patients with QRS &lt; 100 ms and QTc &lt; 450 ms (both p &lt; 0.05). The absence of any pathology on 12-lead ECG had a negative predictive value of 100% for the presence of AL-CA. Conclusion: Standard 12-lead ECG seems to be a method with a relevant negative predictive value for the exclusion of AL-CA. The duration of QRS as well as QTc intervals seem to be a marker of early mortality.

Název v anglickém jazyce

Clinical and Prognostic Implications of Electrocardiography and Holter Monitoring Findings in Patients with Light Chain Cardiac Amyloidosis

Popis výsledku anglicky

Background: Cardiac involvement in light chain amyloidosis (AL-CA) represents an infiltrative heart disease. The aim of the study was to recognize differences between patients suffering from light chain amyloidosis with and without cardiac involvement in 12-lead electrocardiography (ECG) and 24-h Holter ECG monitoring. Methods: We prospectively analyzed data in 39 (median 66 [IQR 62;71] years, 62% males) consecutive patients with AL amyloidosis. Results: Out of all patients, AL-CA was confirmed in 26 (67%) subjects. All patients with AL-CA manifested at least one pathology ECG, which contrasted with a low prevalence of abnormal ECG findings in patients without cardiac involvement (54%), p &lt; 0.001. Abnormal Holter ECG findings were documented in 77% and 62% of patients with and without AL-CA. During 19 (7;59) months of follow-up, 19 (73%) patients with AL-CA died. The mortality rate was significantly lower in patients with QRS &lt; 100 ms and QTc &lt; 450 ms (both p &lt; 0.05). The absence of any pathology on 12-lead ECG had a negative predictive value of 100% for the presence of AL-CA. Conclusion: Standard 12-lead ECG seems to be a method with a relevant negative predictive value for the exclusion of AL-CA. The duration of QRS as well as QTc intervals seem to be a marker of early mortality.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bratislavské lekárske listy / Bratislava Medical Journal

ISSN

0006-9248

e-ISSN

1336-0345

Svazek periodika

126

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

9

Strana od-do

202-210

Kód UT WoS článku

001465540600014

EID výsledku v databázi Scopus

2-s2.0-85217688089