Diagnostic and prognostic value of QRS duration and QTc interval in patients with suspected myocardial infarction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F18%3A00069079" target="_blank" >RIV/65269705:_____/18:00069079 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/18:00104901

Výsledek na webu

<a href="https://journals.viamedica.pl/cardiology_journal/article/view/CJ.a2018.0033/46674" target="_blank" >https://journals.viamedica.pl/cardiology_journal/article/view/CJ.a2018.0033/46674</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5603/CJ.a2018.0033" target="_blank" >10.5603/CJ.a2018.0033</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Diagnostic and prognostic value of QRS duration and QTc interval in patients with suspected myocardial infarction

Popis výsledku v původním jazyce

Background: While prolongation of QRS duration and QTc interval during acute myocardial infarction (AMI) has been reported in animals, limited data is available for these readily available electrocardiography (ECG) markers in humans. Methods: Diagnostic and prognostic value of QRS duration and QTc interval in patients with suspected AMI in a prospective diagnostic multicentre study were prospectively assessed, Digital 12-lead ECGs were recorded at presentation. QRS duration and QTc interval were automatically calculated in a blinded fashion. Final diagnosis was adjudicated by two independent cardiologists. The prognostic endpoint was all-cause mortality during 24 months of follow-up. Results: Among 4042 patients, AMI was the final diagnosis in 19% of patients. Median QRS duration and median QTc interval were significantly greater in patients with AMI compared to those with other final diagnoses (98 ms (IQR 88-108] vs. 94 ms [IQR 86-102] and 436 ms [IQR 414-462] vs. 425 ms [IQR 407-445], p &lt; 0.001 for both comparisons). The diagnostic value of both ECG signatures however was only modest (AUC 0.56 and 0.60). Cumulative mortality rates after 2 years were 15.9% vs. 5.6% in patients with a QRS &gt; 120 ms compared to a QRS duration &lt;= 120 ms (p &lt; 0.001), and 11.4% vs. 4.3% in patients with a QTc &gt; 440 ms compared to a QRS duration &lt;= 440 ms (p &lt; 0.001). After adjustment for age and important ECG and clinical parameters, the QTc interval but not QRS duration remained an independent predictor of mortality. Conclusions: Prolongation of QRS duration &gt; 120 ms and QTc interval &gt; 440 ms predict mortality in patients with suspected AMI, but do not add diagnostic value.

Název v anglickém jazyce

Diagnostic and prognostic value of QRS duration and QTc interval in patients with suspected myocardial infarction

Popis výsledku anglicky

Background: While prolongation of QRS duration and QTc interval during acute myocardial infarction (AMI) has been reported in animals, limited data is available for these readily available electrocardiography (ECG) markers in humans. Methods: Diagnostic and prognostic value of QRS duration and QTc interval in patients with suspected AMI in a prospective diagnostic multicentre study were prospectively assessed, Digital 12-lead ECGs were recorded at presentation. QRS duration and QTc interval were automatically calculated in a blinded fashion. Final diagnosis was adjudicated by two independent cardiologists. The prognostic endpoint was all-cause mortality during 24 months of follow-up. Results: Among 4042 patients, AMI was the final diagnosis in 19% of patients. Median QRS duration and median QTc interval were significantly greater in patients with AMI compared to those with other final diagnoses (98 ms (IQR 88-108] vs. 94 ms [IQR 86-102] and 436 ms [IQR 414-462] vs. 425 ms [IQR 407-445], p &lt; 0.001 for both comparisons). The diagnostic value of both ECG signatures however was only modest (AUC 0.56 and 0.60). Cumulative mortality rates after 2 years were 15.9% vs. 5.6% in patients with a QRS &gt; 120 ms compared to a QRS duration &lt;= 120 ms (p &lt; 0.001), and 11.4% vs. 4.3% in patients with a QTc &gt; 440 ms compared to a QRS duration &lt;= 440 ms (p &lt; 0.001). After adjustment for age and important ECG and clinical parameters, the QTc interval but not QRS duration remained an independent predictor of mortality. Conclusions: Prolongation of QRS duration &gt; 120 ms and QTc interval &gt; 440 ms predict mortality in patients with suspected AMI, but do not add diagnostic value.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cardiology Journal

ISSN

1897-5593

e-ISSN

—

Svazek periodika

25

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

10

Strana od-do

601-610

Kód UT WoS článku

000449351400009

EID výsledku v databázi Scopus

2-s2.0-85056255777