A product of immunoreactive trypsinogen and pancreatitis-associated protein as second-tier strategy in cystic fibrosis newborn screening

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F16%3AN0000035" target="_blank" >RIV/00064173:_____/16:N0000035 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/16:10332816 RIV/00216208:11120/16:43912047 RIV/00064203:_____/16:10332816

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jcf.2016.07.002" target="_blank" >http://dx.doi.org/10.1016/j.jcf.2016.07.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jcf.2016.07.002" target="_blank" >10.1016/j.jcf.2016.07.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A product of immunoreactive trypsinogen and pancreatitis-associated protein as second-tier strategy in cystic fibrosis newborn screening

Popis výsledku v původním jazyce

Background: In cystic fibrosis newborn screening (CFNBS), immunoreactive trypsinogen (IRT) and pancreatitis-associated protein (PAP) can be used as screening parameters. We evaluated the IRT. x. PAP product as second-tier parameter in CFNBS in newborns with elevated IRT. Methods: Data on 410,111 screened newborns including 78 patients with classical cystic fibrosis (CF) from two European centers were retrospectively analyzed by discrimination analysis to identify a screening protocol with optimal cutoffs. We also studied differences in PAP measurement methods and the association of IRT and PAP with age. Results: PAP values differed systematically between fluorometric and photometric assays. The IRT. x. PAP product showed better discrimination for classical CF than PAP only as second-tier screening parameter (p . <. 0.001). In CF patients, IRT decreased while PAP values remained high over years. In newborns without CF, IRT decreased after birth over weeks while PAP increased within days. Conclusions: The IRT. x. PAP product performs well as second-tier cutoff parameter for CFNBS. Screening quality parameters depend on the analytic method and on age at blood collection.

Název v anglickém jazyce

A product of immunoreactive trypsinogen and pancreatitis-associated protein as second-tier strategy in cystic fibrosis newborn screening

Popis výsledku anglicky

Background: In cystic fibrosis newborn screening (CFNBS), immunoreactive trypsinogen (IRT) and pancreatitis-associated protein (PAP) can be used as screening parameters. We evaluated the IRT. x. PAP product as second-tier parameter in CFNBS in newborns with elevated IRT. Methods: Data on 410,111 screened newborns including 78 patients with classical cystic fibrosis (CF) from two European centers were retrospectively analyzed by discrimination analysis to identify a screening protocol with optimal cutoffs. We also studied differences in PAP measurement methods and the association of IRT and PAP with age. Results: PAP values differed systematically between fluorometric and photometric assays. The IRT. x. PAP product showed better discrimination for classical CF than PAP only as second-tier screening parameter (p . <. 0.001). In CF patients, IRT decreased while PAP values remained high over years. In newborns without CF, IRT decreased after birth over weeks while PAP increased within days. Conclusions: The IRT. x. PAP product performs well as second-tier cutoff parameter for CFNBS. Screening quality parameters depend on the analytic method and on age at blood collection.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FG - Pediatrie

OECD FORD obor

—

Projekt

<a href="/cs/project/LM2015091" target="_blank" >LM2015091: Národní centrum lékařské genomiky</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Cystic Fibrosis

ISSN

1569-1993

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

752-758

Kód UT WoS článku

000390517700010

EID výsledku v databázi Scopus

2-s2.0-84979273032