Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F20%3AN0000196" target="_blank" >RIV/00064173:_____/20:N0000196 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/20:00539306 RIV/00216208:11140/20:10415704 RIV/00216208:11110/20:10415704 RIV/00216208:11120/20:43920608

Výsledek na webu

<a href="https://doi.org/10.3892/or.2020.7774" target="_blank" >https://doi.org/10.3892/or.2020.7774</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/or.2020.7774" target="_blank" >10.3892/or.2020.7774</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients

Popis výsledku v původním jazyce

Accumulation of non-specific structural chromosomal aberrations (CAs) and telomere shortening contribute to genome instability, which constitutes as one of the hallmarks of cancer. CAs arise due to direct DNA damage or telomere shortening. CAs in peripheral blood lymphocytes (PBL), which are considered to be markers of exposure, have been previously reported to serve a role in the pathophysiology and progression of cancer through mechanisms that are poorly understood. In addition, the prognostic relevance of telomere length (TL) in patients with cancer remains to be elucidated. In the present study, CAs and TL in PBL isolated from patients with newly diagnosed cancer (151 breast, 96 colorectal, 90 lung) and 335 cancer-free control individuals were investigated. These results were then correlated with clinicopathological factors and follow-up data. The accumulation of CAs in PBL was observed with increased susceptibility to breast and lung cancer (P<0.0001), while individuals with longer TL were found to be at a higher risk of breast cancer (P<0.0001). Increased chromatid-type aberrations were also revealed to be associated with lower overall survival of patients with breast and colorectal cancers using a multivariate model. Compared with control individuals, no association was observed between TL and CAs or age in patients with cancer. In conclusion, the present study demonstrates the association between CAs/TL in PBL and the susceptibility, prognosis and survival of patients with breast, colorectal and lung cancer.

Název v anglickém jazyce

Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients

Popis výsledku anglicky

Accumulation of non-specific structural chromosomal aberrations (CAs) and telomere shortening contribute to genome instability, which constitutes as one of the hallmarks of cancer. CAs arise due to direct DNA damage or telomere shortening. CAs in peripheral blood lymphocytes (PBL), which are considered to be markers of exposure, have been previously reported to serve a role in the pathophysiology and progression of cancer through mechanisms that are poorly understood. In addition, the prognostic relevance of telomere length (TL) in patients with cancer remains to be elucidated. In the present study, CAs and TL in PBL isolated from patients with newly diagnosed cancer (151 breast, 96 colorectal, 90 lung) and 335 cancer-free control individuals were investigated. These results were then correlated with clinicopathological factors and follow-up data. The accumulation of CAs in PBL was observed with increased susceptibility to breast and lung cancer (P<0.0001), while individuals with longer TL were found to be at a higher risk of breast cancer (P<0.0001). Increased chromatid-type aberrations were also revealed to be associated with lower overall survival of patients with breast and colorectal cancers using a multivariate model. Compared with control individuals, no association was observed between TL and CAs or age in patients with cancer. In conclusion, the present study demonstrates the association between CAs/TL in PBL and the susceptibility, prognosis and survival of patients with breast, colorectal and lung cancer.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Oncology Reports

ISSN

1021-335X

e-ISSN

1791-2431

Svazek periodika

44

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

12

Strana od-do

2219-2230

Kód UT WoS článku

000582501500039

EID výsledku v databázi Scopus

2-s2.0-85092093899