Structural chromosomal aberrations as potential risk markers in incident cancer patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295986" target="_blank" >RIV/00216208:11110/15:10295986 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/15:00451439 RIV/00216208:11130/15:10295986 RIV/00216208:11140/15:10295986 RIV/00216208:11120/15:43909567

Výsledek na webu

<a href="http://dx.doi.org/10.1093/mutage/gev018" target="_blank" >http://dx.doi.org/10.1093/mutage/gev018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/mutage/gev018" target="_blank" >10.1093/mutage/gev018</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Structural chromosomal aberrations as potential risk markers in incident cancer patients

Popis výsledku v původním jazyce

Epidemiological prospective studies have shown that increased chromosomal aberrations (CAs) in peripheral blood lymphocytes may predict cancer risk. Here, we report CAs in newly diagnosed 101 colorectal, 87 lung and 158 breast cancer patients and corresponding healthy controls. Strong differences in distributions of aberrant cells (ACs), CAs, chromatid-type aberrations (CTAs) and chromosome-type aberrations (CSAs) were observed in lung and breast cancer patients as compared to healthy controls. In colorectal cancer (CRC) patients, only CTAs were significantly elevated. Binary logistic regression, adjusted for main confounders, indicates that all the analysed cytogenetic parameters along with smoking were significantly associated with breast and lung cancer risks. Significant differences in terminal deletions between breast cancer patients and corresponding female controls were recorded (0.39 vs. 0.18; P {= 0.05). We did not find any association of CAs with TNM (tumor nodus metastasis)

Název v anglickém jazyce

Structural chromosomal aberrations as potential risk markers in incident cancer patients

Popis výsledku anglicky

Epidemiological prospective studies have shown that increased chromosomal aberrations (CAs) in peripheral blood lymphocytes may predict cancer risk. Here, we report CAs in newly diagnosed 101 colorectal, 87 lung and 158 breast cancer patients and corresponding healthy controls. Strong differences in distributions of aberrant cells (ACs), CAs, chromatid-type aberrations (CTAs) and chromosome-type aberrations (CSAs) were observed in lung and breast cancer patients as compared to healthy controls. In colorectal cancer (CRC) patients, only CTAs were significantly elevated. Binary logistic regression, adjusted for main confounders, indicates that all the analysed cytogenetic parameters along with smoking were significantly associated with breast and lung cancer risks. Significant differences in terminal deletions between breast cancer patients and corresponding female controls were recorded (0.39 vs. 0.18; P {= 0.05). We did not find any association of CAs with TNM (tumor nodus metastasis)

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mutagenesis

ISSN

0267-8357

e-ISSN

—

Svazek periodika

30

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

557-563

Kód UT WoS článku

000357885900011

EID výsledku v databázi Scopus

2-s2.0-84936748157