Clinical Features, Outcomes, and Response to Corticosteroid Treatment of Acute Tubulointerstitial Nephritis: A Single-Centre Retrospective Cohort Study in the Czech Republic

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F24%3A43926224" target="_blank" >RIV/00064173:_____/24:43926224 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/24:10471972 RIV/00216208:11120/24:43926224 RIV/00064211:_____/24:W0000065 RIV/00064165:_____/24:10471972

Výsledek na webu

<a href="https://doi.org/10.1159/000535415" target="_blank" >https://doi.org/10.1159/000535415</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000535415" target="_blank" >10.1159/000535415</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Clinical Features, Outcomes, and Response to Corticosteroid Treatment of Acute Tubulointerstitial Nephritis: A Single-Centre Retrospective Cohort Study in the Czech Republic

Popis výsledku v původním jazyce

Introduction: Acute tubulointerstitial nephritis (ATIN) is a well-recognized cause of acute kidney injury (AKI) due to the tubulointerstitial inflammation. The aim of this study was to explore the clinical features, outcomes, and responses to corticosteroid treatment in patients with ATIN. Methods: Patients with biopsy proven ATIN, who were diagnosed between 1994-2016 at the Department of Nephrology, Charles University, First Faculty of Medicine and General University Hospital in Prague, were included in the study. Patient demographics, the aetiological and clinical features, the treatment given, and the outcome at one year of follow up were extracted from patient records. Results: A total of 103 ATIN patients were analysed, of which 68 had been treated with corticosteroids. There was no significant difference in the median serum creatinine 280 (169-569) mu mol/l in the conservatively managed group vs. 374 (249-558) mu mol/l in the corticosteroid treated group, p = 0.18 and dependence on dialysis treatment at baseline at the time of biopsy (10.3% vs 8.6%). During the one year follow up, those ATIN patients who had been treated with corticosteroids did better and showed greater improvement in kidney function, determined as serum creatinine difference from baseline and from one month over one year period (p=0.001). Conclusions: This single center retrospective cohort study supports the beneficial role of the administration of corticosteroid therapy in the management of ATIN.

Název v anglickém jazyce

Clinical Features, Outcomes, and Response to Corticosteroid Treatment of Acute Tubulointerstitial Nephritis: A Single-Centre Retrospective Cohort Study in the Czech Republic

Popis výsledku anglicky

Introduction: Acute tubulointerstitial nephritis (ATIN) is a well-recognized cause of acute kidney injury (AKI) due to the tubulointerstitial inflammation. The aim of this study was to explore the clinical features, outcomes, and responses to corticosteroid treatment in patients with ATIN. Methods: Patients with biopsy proven ATIN, who were diagnosed between 1994-2016 at the Department of Nephrology, Charles University, First Faculty of Medicine and General University Hospital in Prague, were included in the study. Patient demographics, the aetiological and clinical features, the treatment given, and the outcome at one year of follow up were extracted from patient records. Results: A total of 103 ATIN patients were analysed, of which 68 had been treated with corticosteroids. There was no significant difference in the median serum creatinine 280 (169-569) mu mol/l in the conservatively managed group vs. 374 (249-558) mu mol/l in the corticosteroid treated group, p = 0.18 and dependence on dialysis treatment at baseline at the time of biopsy (10.3% vs 8.6%). During the one year follow up, those ATIN patients who had been treated with corticosteroids did better and showed greater improvement in kidney function, determined as serum creatinine difference from baseline and from one month over one year period (p=0.001). Conclusions: This single center retrospective cohort study supports the beneficial role of the administration of corticosteroid therapy in the management of ATIN.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

<a href="/cs/project/LX22NPO5104" target="_blank" >LX22NPO5104: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Kidney &amp; Blood Pressure Research

ISSN

1420-4096

e-ISSN

1423-0143

Svazek periodika

49

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

8

Strana od-do

1-8

Kód UT WoS článku

001111194800001

EID výsledku v databázi Scopus

2-s2.0-85184296852