Sleep-disordered breathing increases mortality in patients with diabetes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F25%3A43927498" target="_blank" >RIV/00064173:_____/25:43927498 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/25:43927498

Výsledek na webu

<a href="https://doi.org/10.5664/jcsm.11320" target="_blank" >https://doi.org/10.5664/jcsm.11320</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5664/jcsm.11320" target="_blank" >10.5664/jcsm.11320</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sleep-disordered breathing increases mortality in patients with diabetes

Popis výsledku v původním jazyce

STUDY OBJECTIVES: Sleep-disordered breathing (SDB) and diabetes mellitus (DM) are often concomitant; however, data on the impact of SDB on mortality in the population with diabetes remain scarce. METHODS: The population from the Sleep Heart Health Study, a multicenter prospective observational study representing 5780 patients with polysomnography and mortality data, including 453 patients with DM, was analyzed to assess the impact of SDB variables and the presence of DM on all-cause, cardiovascular disease (CVD), and non-CVD associated mortality. Survival analysis and proportional hazard regression models were used to calculate the adjusted hazard ratios (aHR) for mortality. RESULTS: Patients with DM and the average SpO(2) &gt;91.4% had significantly lower all-cause (aHR 0.52, CI 0.34-0.80) and CVD mortality risk (aHR 0.44, CI 0.22-0.87) as compared with patients with SpO(2) below this value. Apnea-hypopnea index &gt;31 (aHR 1.58, CI 1.10-2.28) and oxygen desaturation index &gt;13.3 (aHR 1.58, CI 1.10-2.25) were associated with increased all-cause mortality in participants with DM on treatment. Sleep efficiency and proportion of rapid-eye movement (REM) sleep did not have any impact on mortality in patients with DM and thus differed significantly from individuals without DM, where increased all-cause mortality was observed in those with sleep efficiency &lt;81.4% (aHR 0.77, CI 0.68-0.87) or REM sleep &lt;14.9% (aHR 0.78, CI 0.68-0.89). CONCLUSIONS: Patients with diabetes on treatment and moderate to severe sleep-disordered breathing experience increased all-cause mortality. Reduced average oxygen saturation predicted both all-cause and cardiovascular death in the population with diabetes.

Název v anglickém jazyce

Sleep-disordered breathing increases mortality in patients with diabetes

Popis výsledku anglicky

STUDY OBJECTIVES: Sleep-disordered breathing (SDB) and diabetes mellitus (DM) are often concomitant; however, data on the impact of SDB on mortality in the population with diabetes remain scarce. METHODS: The population from the Sleep Heart Health Study, a multicenter prospective observational study representing 5780 patients with polysomnography and mortality data, including 453 patients with DM, was analyzed to assess the impact of SDB variables and the presence of DM on all-cause, cardiovascular disease (CVD), and non-CVD associated mortality. Survival analysis and proportional hazard regression models were used to calculate the adjusted hazard ratios (aHR) for mortality. RESULTS: Patients with DM and the average SpO(2) &gt;91.4% had significantly lower all-cause (aHR 0.52, CI 0.34-0.80) and CVD mortality risk (aHR 0.44, CI 0.22-0.87) as compared with patients with SpO(2) below this value. Apnea-hypopnea index &gt;31 (aHR 1.58, CI 1.10-2.28) and oxygen desaturation index &gt;13.3 (aHR 1.58, CI 1.10-2.25) were associated with increased all-cause mortality in participants with DM on treatment. Sleep efficiency and proportion of rapid-eye movement (REM) sleep did not have any impact on mortality in patients with DM and thus differed significantly from individuals without DM, where increased all-cause mortality was observed in those with sleep efficiency &lt;81.4% (aHR 0.77, CI 0.68-0.87) or REM sleep &lt;14.9% (aHR 0.78, CI 0.68-0.89). CONCLUSIONS: Patients with diabetes on treatment and moderate to severe sleep-disordered breathing experience increased all-cause mortality. Reduced average oxygen saturation predicted both all-cause and cardiovascular death in the population with diabetes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Sleep Medicine

ISSN

1550-9389

e-ISSN

1550-9397

Svazek periodika

21

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

89-99

Kód UT WoS článku

001652409900001

EID výsledku v databázi Scopus

2-s2.0-85214324051