Reactive Oxygen Species and Antioxidants in Pulmonary Hypertension and Right Heart Failure

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F14%3A%230001020" target="_blank" >RIV/00064190:_____/14:#0001020 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-3-642-30018-9_123" target="_blank" >http://dx.doi.org/10.1007/978-3-642-30018-9_123</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-642-30018-9_123" target="_blank" >10.1007/978-3-642-30018-9_123</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Reactive Oxygen Species and Antioxidants in Pulmonary Hypertension and Right Heart Failure

Popis výsledku v původním jazyce

Pulmonary hypertension is a devastating condition, and currently available treatment options have not provided satisfactory results with regard to the prognosis of patients. Increased pulmonary arterial resistance stains the right heart, ultimately leading to right heart failure and death. Thus, new therapeutic strategies are needed. Evidence suggests that the mechanisms of the development of pulmonary hypertension, in particular pulmonary vascular remodeling, and the development of right heart remodeling involve reactive oxygen species. In animal models of pulmonary hypertension, various molecules with antioxidant properties have been shown to attenuate pulmonary vascular as well as right ventricular remodeling. Evidence for the benefit of antioxidanttherapy in human pulmonary hypertension patients is, however, lacking. This chapter compiles information on cell, animal, and human studies that provide evidence for the role of reactive oxygen species and the beneficial effects of antio

Název v anglickém jazyce

Reactive Oxygen Species and Antioxidants in Pulmonary Hypertension and Right Heart Failure

Popis výsledku anglicky

Pulmonary hypertension is a devastating condition, and currently available treatment options have not provided satisfactory results with regard to the prognosis of patients. Increased pulmonary arterial resistance stains the right heart, ultimately leading to right heart failure and death. Thus, new therapeutic strategies are needed. Evidence suggests that the mechanisms of the development of pulmonary hypertension, in particular pulmonary vascular remodeling, and the development of right heart remodeling involve reactive oxygen species. In animal models of pulmonary hypertension, various molecules with antioxidant properties have been shown to attenuate pulmonary vascular as well as right ventricular remodeling. Evidence for the benefit of antioxidanttherapy in human pulmonary hypertension patients is, however, lacking. This chapter compiles information on cell, animal, and human studies that provide evidence for the role of reactive oxygen species and the beneficial effects of antio

Druh

C - Kapitola v odborné knize

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Systems Biology of Free Radicals and Antioxidants

ISBN

978-3-642-30017-2

Počet stran výsledku

16

Strana od-do

1671-1687

Počet stran knihy

4109

Název nakladatele

Springer Berlin Heidelberg

Místo vydání

Berlín

Kód UT WoS kapitoly

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