7C.06: Soluble receptor for advanced glycation end-products and increased aortic stiffness in a general population.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F15%3A%230001151" target="_blank" >RIV/00064190:_____/15:#0001151 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1097/01.hjh.0000467613.31106.3d" target="_blank" >http://dx.doi.org/10.1097/01.hjh.0000467613.31106.3d</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/01.hjh.0000467613.31106.3d" target="_blank" >10.1097/01.hjh.0000467613.31106.3d</a>

Jazyk výsledku

angličtina

Název v původním jazyce

7C.06: Soluble receptor for advanced glycation end-products and increased aortic stiffness in a general population.

Popis výsledku v původním jazyce

OBJECTIVE: It has been suggested that accumulation of advanced glycation end-products (AGE[Combining Acute Accent]s) are involved in several pathophysiological processes in vessel wall. We hypothesized that low levels of the soluble receptor for AGE[Combining Acute Accent]s (sRAGE) might be associated with increased arterial stiffness as manifestation of vascular ageing in general population. DESIGN AND METHOD: In a cross-sectional design, we analyzed 1077 subjects from the Czech post-MONICA study. Aortic pulse wave velocity (aPWV) were measured using a Sphygmocor device. sRAGE concentrations were assessed in freshly frozen samples by ELISA methods(R&D Systems) RESULTS: : Aortic PWV significantly (p < 0.0001) increased across the sRAGE quartiles. 1 m/sec of aortic aPWV was associated with 37% increased risk of low sRAGE (<918 pg/mL, bottom quartile) with p value=0.018. In a categorized manner, subjects in the bottom quartile of sRAGE had more than two-times higher risk of raised aortic PWV (= > 9.3 m/sec), but only in non-diabetic hypertensive patients (corresponding odds ratio, adjusted for all potential confounders was 2.05 (95%CI: 1.26-3.32), p = 0.004. In contrast, low sRAGE was by similar regression models rejected as independent predictor of raised aortic aPWV in normotensive or diabetic subject. CONCLUSIONS: Low circulating sRAGE was independently associated with increased arterial stiffness in general population- based sample, but only in hypertensive non-diabetic patients.

Název v anglickém jazyce

7C.06: Soluble receptor for advanced glycation end-products and increased aortic stiffness in a general population.

Popis výsledku anglicky

OBJECTIVE: It has been suggested that accumulation of advanced glycation end-products (AGE[Combining Acute Accent]s) are involved in several pathophysiological processes in vessel wall. We hypothesized that low levels of the soluble receptor for AGE[Combining Acute Accent]s (sRAGE) might be associated with increased arterial stiffness as manifestation of vascular ageing in general population. DESIGN AND METHOD: In a cross-sectional design, we analyzed 1077 subjects from the Czech post-MONICA study. Aortic pulse wave velocity (aPWV) were measured using a Sphygmocor device. sRAGE concentrations were assessed in freshly frozen samples by ELISA methods(R&D Systems) RESULTS: : Aortic PWV significantly (p < 0.0001) increased across the sRAGE quartiles. 1 m/sec of aortic aPWV was associated with 37% increased risk of low sRAGE (<918 pg/mL, bottom quartile) with p value=0.018. In a categorized manner, subjects in the bottom quartile of sRAGE had more than two-times higher risk of raised aortic PWV (= > 9.3 m/sec), but only in non-diabetic hypertensive patients (corresponding odds ratio, adjusted for all potential confounders was 2.05 (95%CI: 1.26-3.32), p = 0.004. In contrast, low sRAGE was by similar regression models rejected as independent predictor of raised aortic aPWV in normotensive or diabetic subject. CONCLUSIONS: Low circulating sRAGE was independently associated with increased arterial stiffness in general population- based sample, but only in hypertensive non-diabetic patients.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of hypertension

ISSN

0263-6352

e-ISSN

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Svazek periodika

33

Číslo periodika v rámci svazku

Suppl 1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

2

Strana od-do

"e97"-"e98"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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