Soluble receptor for advanced glycation end products and increased aortic stiffness in the general population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00066073" target="_blank" >RIV/00159816:_____/16:00066073 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/16:10323353 RIV/00669806:_____/16:10323353 RIV/00064190:_____/16:N0000039 RIV/00216208:11110/16:10323353

Výsledek na webu

<a href="http://dx.doi.org/10.1038/hr.2015.131" target="_blank" >http://dx.doi.org/10.1038/hr.2015.131</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/hr.2015.131" target="_blank" >10.1038/hr.2015.131</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Soluble receptor for advanced glycation end products and increased aortic stiffness in the general population

Popis výsledku v původním jazyce

It has been suggested that accumulation of advanced glycation end products (AGEs) is involved in several pathophysiological processes in the vessel wall. We hypothesized that low levels of the soluble receptor for AGEs (sRAGE) might be associated with increased arterial stiffness, a manifestation of vascular ageing in the general population. Using a cross-sectional design, we analyzed 1077 subjects from the Czech post-MONICA study. The aortic pulse wave velocity (aPWV) was measured using a Sphygmocor device. sRAGE concentrations were assessed in frozen samples using enzyme-linked immunosorbent assay methods (R&D Systems). aPWV significantly (P<0.0001) increased across the sRAGE quartiles. An aPWV of 1 m s(-1) was associated with a 37% increase in the risk of low sRAGE (<918 pg ml(-1), bottom quartile; P-value 0.018). In a categorized manner, subjects in the bottom sRAGE quartile had an odds ratio of an increased aPWV (}= 9.3m s(-1)), adjusted for all potential confounders of 2.05 (95% confidence interval: 1.26-3.32; P 0.004), but this was only the case for non-diabetic hypertensive patients. In contrast, a low sRAGE was rejected as an independent predictor of an increased aPWV in normotensive or diabetic subjects using similar regression models. In conclusion, low circulating sRAGE was independently associated with increased arterial stiffness in a general population-based sample, but this was only observed in hypertensive non-diabetic patients.

Název v anglickém jazyce

Soluble receptor for advanced glycation end products and increased aortic stiffness in the general population

Popis výsledku anglicky

It has been suggested that accumulation of advanced glycation end products (AGEs) is involved in several pathophysiological processes in the vessel wall. We hypothesized that low levels of the soluble receptor for AGEs (sRAGE) might be associated with increased arterial stiffness, a manifestation of vascular ageing in the general population. Using a cross-sectional design, we analyzed 1077 subjects from the Czech post-MONICA study. The aortic pulse wave velocity (aPWV) was measured using a Sphygmocor device. sRAGE concentrations were assessed in frozen samples using enzyme-linked immunosorbent assay methods (R&D Systems). aPWV significantly (P<0.0001) increased across the sRAGE quartiles. An aPWV of 1 m s(-1) was associated with a 37% increase in the risk of low sRAGE (<918 pg ml(-1), bottom quartile; P-value 0.018). In a categorized manner, subjects in the bottom sRAGE quartile had an odds ratio of an increased aPWV (}= 9.3m s(-1)), adjusted for all potential confounders of 2.05 (95% confidence interval: 1.26-3.32; P 0.004), but this was only the case for non-diabetic hypertensive patients. In contrast, a low sRAGE was rejected as an independent predictor of an increased aPWV in normotensive or diabetic subjects using similar regression models. In conclusion, low circulating sRAGE was independently associated with increased arterial stiffness in a general population-based sample, but this was only observed in hypertensive non-diabetic patients.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Hypertension Research

ISSN

0916-9636

e-ISSN

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Svazek periodika

39

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

266-271

Kód UT WoS článku

000373847300014

EID výsledku v databázi Scopus

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