New insights in the diagnosis and treatment of amyotrophic lateral sclerosis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F18%3AN0000040" target="_blank" >RIV/00064190:_____/18:N0000040 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.14735/amcsnn2018546" target="_blank" >http://dx.doi.org/10.14735/amcsnn2018546</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14735/amcsnn2018546" target="_blank" >10.14735/amcsnn2018546</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
New insights in the diagnosis and treatment of amyotrophic lateral sclerosis
Popis výsledku v původním jazyce
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of increased prevalence with age. The main findings are loss of peripheral and central motoneurons and their pathways with extraocular and sphincter muscle sparing. These are classical forms of ALS with loss of central and peripheral motoneurons, as well as progressive bulbar paralysis with impairment of bulbar muscles. Progressive muscle atrophy with only peripheral motoneuron lesions and primary lateral sclerosis with only central motoneuron involvement are rarely found. There are some forms of ALS associated with dementia (frontotemporal lobar dementia-motor neuron disease [FTLDMND]) with behavioral changes, cognitive and executive dysfunction. The cause of ALS has not yet been elucidated. It is a chain of follow-up events, at the end of which is cell death in selective subpopulations of neurons. In the present paper, we describe in detail the neuropathological findings and molecular genetic analysis in familial forms of ALS. A specific drug for this disease is still unknown. Neuroprotective drugs (such as riluzole and recently edaravon) have an ambiguous effect. Symptomatic treatment is designed to manage concomitant manifestations. Different treatment options are discus sed in detail.
Název v anglickém jazyce
New insights in the diagnosis and treatment of amyotrophic lateral sclerosis
Popis výsledku anglicky
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of increased prevalence with age. The main findings are loss of peripheral and central motoneurons and their pathways with extraocular and sphincter muscle sparing. These are classical forms of ALS with loss of central and peripheral motoneurons, as well as progressive bulbar paralysis with impairment of bulbar muscles. Progressive muscle atrophy with only peripheral motoneuron lesions and primary lateral sclerosis with only central motoneuron involvement are rarely found. There are some forms of ALS associated with dementia (frontotemporal lobar dementia-motor neuron disease [FTLDMND]) with behavioral changes, cognitive and executive dysfunction. The cause of ALS has not yet been elucidated. It is a chain of follow-up events, at the end of which is cell death in selective subpopulations of neurons. In the present paper, we describe in detail the neuropathological findings and molecular genetic analysis in familial forms of ALS. A specific drug for this disease is still unknown. Neuroprotective drugs (such as riluzole and recently edaravon) have an ambiguous effect. Symptomatic treatment is designed to manage concomitant manifestations. Different treatment options are discus sed in detail.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30103 - Neurosciences (including psychophysiology)
Návaznosti výsledku
Projekt
—
Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
ČESKÁ A SLOVENSKÁ NEUROLOGIE A NEUROCHIRURGIE
ISSN
1210-7859
e-ISSN
1802-4041
Svazek periodika
81
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
9
Strana od-do
546-554
Kód UT WoS článku
000446004700007
EID výsledku v databázi Scopus
2-s2.0-85061004041