Chromosomal aberrations in etiology of early reproductive failure: analysis of 233 cases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F19%3AN0000091" target="_blank" >RIV/00064190:_____/19:N0000091 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.actualgyn.com/pdf/en_2019_227.pdf" target="_blank" >https://www.actualgyn.com/pdf/en_2019_227.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Chromosomal aberrations in etiology of early reproductive failure: analysis of 233 cases

Popis výsledku v původním jazyce

Chromosomal aberrations are common cause of early miscarriage. Possible presence of chromosomal aberration may be assessed by cytogenetic examination of the aborted fetus tissue. In our study from the Institute of Biology and Medical Genetics of the First Faculty of Medicine of Charles University and General University Hospital in Prague we analysed tissue sample from 233 early spontaneous or missed abortions. In 212 cases the cultivation process was successful. Among those - we identified 52 cases with chromosomal aberration (24,5 %). Most common aberrations were - trisomy 21, monosomy X, triploidy and trisomies of chromosomes 16 and 22. Our overall incidence of aberrations was lower - compared to similar studies. According to other indicators we suppose that this may be caused by the higher incidence of maternal cells contamination - but this phenomenon cannot be completely excluded while using classical karyotyping. We also confirmed higher incidence of chromosomal aberrations in the miscarriage cases in elder mothers and furthermore we found higher incidence of aberrations in cases from higher gestation weeks. Both trends were statistically significant.

Název v anglickém jazyce

Chromosomal aberrations in etiology of early reproductive failure: analysis of 233 cases

Popis výsledku anglicky

Chromosomal aberrations are common cause of early miscarriage. Possible presence of chromosomal aberration may be assessed by cytogenetic examination of the aborted fetus tissue. In our study from the Institute of Biology and Medical Genetics of the First Faculty of Medicine of Charles University and General University Hospital in Prague we analysed tissue sample from 233 early spontaneous or missed abortions. In 212 cases the cultivation process was successful. Among those - we identified 52 cases with chromosomal aberration (24,5 %). Most common aberrations were - trisomy 21, monosomy X, triploidy and trisomies of chromosomes 16 and 22. Our overall incidence of aberrations was lower - compared to similar studies. According to other indicators we suppose that this may be caused by the higher incidence of maternal cells contamination - but this phenomenon cannot be completely excluded while using classical karyotyping. We also confirmed higher incidence of chromosomal aberrations in the miscarriage cases in elder mothers and furthermore we found higher incidence of aberrations in cases from higher gestation weeks. Both trends were statistically significant.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Aktuální gynekologie a porodnictví

ISSN

1803-9588

e-ISSN

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Svazek periodika

11

Číslo periodika v rámci svazku

2019

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

23-26

Kód UT WoS článku

000470753800001

EID výsledku v databázi Scopus

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