Evaluation of presepsin as a diagnostic tool in newborns with risk of early-onset neonatal sepsis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F22%3AN0000128" target="_blank" >RIV/00064190:_____/22:N0000128 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/23:10454193 RIV/00064203:_____/23:10454193 RIV/00064190:_____/23:10001061 RIV/00216208:11110/23:10454193 RIV/00064165:_____/23:10454193

Výsledek na webu

<a href="https://doi.org/10.3389/fped.2022.1019825" target="_blank" >https://doi.org/10.3389/fped.2022.1019825</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fped.2022.1019825" target="_blank" >10.3389/fped.2022.1019825</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of presepsin as a diagnostic tool in newborns with risk of early-onset neonatal sepsis

Popis výsledku v původním jazyce

OBJECTIVES: To evaluate the efficacy of presepsin (P-SEP) as a potential biomarker of early-onset neonatal sepsis (EOS) and compare it to other routinely used markers of inflammation. To establish the cut-off values of P-SEP for EOS. STUDY DESIGN: 184 newborns were prospectively recruited between January 2018 to December 2020. Newborns >34th gestational week with suspected infection were included up to 72 h after delivery, and divided into three categories (i.e., unlikely, possible, and probable infection) based on risk factors, clinical symptoms and laboratory results. Values of plasma P-SEP were sequentially analyzed. RESULTS: Median values of P-SEP in newborns with probable infection were significantly higher compared to healthy newborns (p = 0.0000013) and unlikely infection group (p = 0.0000025). The AUC for discriminating the probable infection group from the unlikely infection group was 0.845 (95% Cl: 0.708-0.921). The diagnostic efficacy of P-SEP was highest when used in combination with IL-6 and CRP (0.97; 95% CI: 0.911-0.990). The optimal cut-off value of P-SEP was determined to be 695 ng/L. CONCLUSION: P-SEP, when combined with IL-6 and CRP, may be utilized as a negative predictive marker of EOS (NPV 97.2%, 95% CI: 93.3-101), especially in newborns at low to medium risk of infection.

Název v anglickém jazyce

Evaluation of presepsin as a diagnostic tool in newborns with risk of early-onset neonatal sepsis

Popis výsledku anglicky

OBJECTIVES: To evaluate the efficacy of presepsin (P-SEP) as a potential biomarker of early-onset neonatal sepsis (EOS) and compare it to other routinely used markers of inflammation. To establish the cut-off values of P-SEP for EOS. STUDY DESIGN: 184 newborns were prospectively recruited between January 2018 to December 2020. Newborns >34th gestational week with suspected infection were included up to 72 h after delivery, and divided into three categories (i.e., unlikely, possible, and probable infection) based on risk factors, clinical symptoms and laboratory results. Values of plasma P-SEP were sequentially analyzed. RESULTS: Median values of P-SEP in newborns with probable infection were significantly higher compared to healthy newborns (p = 0.0000013) and unlikely infection group (p = 0.0000025). The AUC for discriminating the probable infection group from the unlikely infection group was 0.845 (95% Cl: 0.708-0.921). The diagnostic efficacy of P-SEP was highest when used in combination with IL-6 and CRP (0.97; 95% CI: 0.911-0.990). The optimal cut-off value of P-SEP was determined to be 695 ng/L. CONCLUSION: P-SEP, when combined with IL-6 and CRP, may be utilized as a negative predictive marker of EOS (NPV 97.2%, 95% CI: 93.3-101), especially in newborns at low to medium risk of infection.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

<a href="/cs/project/NU20-07-00109" target="_blank" >NU20-07-00109: Biomarkery endoteliálního poškození: diagnostický význam endoteliálních mikrovezikul, biomarkerů a mikroRNA u novorozenecké sepse</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

FRONTIERS IN PEDIATRICS

ISSN

2296-2360

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

01/2023

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

12

Strana od-do

Article number 1019825

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85146756145