Artificial Intelligence (AI)-assisted readout method for the evaluation of skin prick automated test results

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F25%3A10001397" target="_blank" >RIV/00064190:_____/25:10001397 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1038/s41467-025-64334-w" target="_blank" >https://doi.org/10.1038/s41467-025-64334-w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41467-025-64334-w" target="_blank" >10.1038/s41467-025-64334-w</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Artificial Intelligence (AI)-assisted readout method for the evaluation of skin prick automated test results

Popis výsledku v původním jazyce

The skin prick test (SPT) is the gold standard for diagnosing allergic sensitization to aeroallergies. The Skin Prick Automated Test (SPAT) device has previously demonstrated reduced variability and more consistent test results compared to manual SPT. The current study aims to develop and validate an artificial intelligence (AI) assisted readout method to support physicians in interpreting skin reactions following SPAT. To train the AI algorithm, 7812 wheals (651 patients) are manually labeled. To validate the AI measurement, the longest wheal diameter of 2604 wheals (217 patients) is measured by the treating physician and compared to the AI measurement. In addition, AI-assisted readout is validated on a separate test cohort of 95 patients (1140 wheals). We demonstrate that the AI measurements of the longest wheal diameter exhibit a strong correlation with the physician&apos;s measurements. The AI algorithm shows a specificity of 98&lt;middle dot&gt;4% and sensitivity of 85&lt;middle dot&gt;0% in determining positive or negative test results in the validation cohort. In the test cohort, physicians adjust 5&lt;middle dot&gt;8% of AI measurements, leading to a change in the test interpretation for only 0&lt;middle dot&gt;5% of cases. AI-assisted readout significantly reduces inter- and intra-observer variability and readout time compared to manual physician measurements. Altogether, the AI-assisted readout method demonstrates high accuracy, with minimal misclassification of test results. Adding AI to SPAT further improves standardization across the SPT process, significantly reducing observer variability and time to readout.

Název v anglickém jazyce

Artificial Intelligence (AI)-assisted readout method for the evaluation of skin prick automated test results

Popis výsledku anglicky

The skin prick test (SPT) is the gold standard for diagnosing allergic sensitization to aeroallergies. The Skin Prick Automated Test (SPAT) device has previously demonstrated reduced variability and more consistent test results compared to manual SPT. The current study aims to develop and validate an artificial intelligence (AI) assisted readout method to support physicians in interpreting skin reactions following SPAT. To train the AI algorithm, 7812 wheals (651 patients) are manually labeled. To validate the AI measurement, the longest wheal diameter of 2604 wheals (217 patients) is measured by the treating physician and compared to the AI measurement. In addition, AI-assisted readout is validated on a separate test cohort of 95 patients (1140 wheals). We demonstrate that the AI measurements of the longest wheal diameter exhibit a strong correlation with the physician&apos;s measurements. The AI algorithm shows a specificity of 98&lt;middle dot&gt;4% and sensitivity of 85&lt;middle dot&gt;0% in determining positive or negative test results in the validation cohort. In the test cohort, physicians adjust 5&lt;middle dot&gt;8% of AI measurements, leading to a change in the test interpretation for only 0&lt;middle dot&gt;5% of cases. AI-assisted readout significantly reduces inter- and intra-observer variability and readout time compared to manual physician measurements. Altogether, the AI-assisted readout method demonstrates high accuracy, with minimal misclassification of test results. Adding AI to SPAT further improves standardization across the SPT process, significantly reducing observer variability and time to readout.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10700 - Other natural sciences

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Communications

ISSN

—

e-ISSN

2041-1723

Svazek periodika

16

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

nestránkováno

Kód UT WoS článku

001586620700003

EID výsledku v databázi Scopus

2-s2.0-105017806289