Characterization of Lymphocyte Subsets in Patients with Common Variable Immunodeficiency Reveals Subsets of Naive Human B Cells Marked by CD24 Expression

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F10%3A6354" target="_blank" >RIV/00064203:_____/10:6354 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/86652036:_____/10:00355461 RIV/00216208:11130/10:6354 RIV/00159816:_____/10:#0000486 RIV/00216224:14110/10:00058956

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Characterization of Lymphocyte Subsets in Patients with Common Variable Immunodeficiency Reveals Subsets of Naive Human B Cells Marked by CD24 Expression

Popis výsledku v původním jazyce

In patients with CVID (which is a defect of immunity-specifically failure of antibody),we usually find less mature memory B cells and multiple naive B cells and B cell specific CD27 (neg) CD21 (neg) CD38 (neg),which are rare in healthy people. In accordance with earlier studies,we have identified two groups of patients: increased frequency of normal naive cells and increased numbers of CD27 (neg) CD21 (neg) CD38 (neg) B cells. Our question was whether we can find developmental relationships between these cell types,that would help us to shed light on normal B cell development and its disorders in CVID.We were able to distinguish the two other subpopulations of naive B cells by functional tests (in vitro differentiation) and the expression of IgM and CD24, which correspond to follicular (FO) I and FO II cells described in mice.We assume that the CD27 (neg) CD21 (neg) CD38 (neg) B cells,which are found in increased numbers in some patients with CVID,develop from FO I cell through loss of

Název v anglickém jazyce

Characterization of Lymphocyte Subsets in Patients with Common Variable Immunodeficiency Reveals Subsets of Naive Human B Cells Marked by CD24 Expression

Popis výsledku anglicky

In patients with CVID (which is a defect of immunity-specifically failure of antibody),we usually find less mature memory B cells and multiple naive B cells and B cell specific CD27 (neg) CD21 (neg) CD38 (neg),which are rare in healthy people. In accordance with earlier studies,we have identified two groups of patients: increased frequency of normal naive cells and increased numbers of CD27 (neg) CD21 (neg) CD38 (neg) B cells. Our question was whether we can find developmental relationships between these cell types,that would help us to shed light on normal B cell development and its disorders in CVID.We were able to distinguish the two other subpopulations of naive B cells by functional tests (in vitro differentiation) and the expression of IgM and CD24, which correspond to follicular (FO) I and FO II cells described in mice.We assume that the CD27 (neg) CD21 (neg) CD38 (neg) B cells,which are found in increased numbers in some patients with CVID,develop from FO I cell through loss of

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Immunology

ISSN

0022-1767

e-ISSN

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Svazek periodika

185

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000284311500007

EID výsledku v databázi Scopus

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